Fox Benjamin, Saxena Nishkarsh, Schuppener Leah, Maursetter Laura
University of Wisconsin School of Medicine and Public Health, Madison Wisconsin, USA.
Southwest Kidney Specialists, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Case Rep Nephrol. 2018 Dec 23;2018:8641893. doi: 10.1155/2018/8641893. eCollection 2018.
Acute oxalate nephropathy (AON) is an increasingly recognized cause of acute kidney injury (AKI). Herein, we present two cases of biopsy-proven acute oxalate nephropathy in patients with gastrointestinal malabsorption, coincidentally both stemming from cholangiocarcinoma. The first is a 73-year-old male who presented with syncope and was found to have severe, oliguric AKI in the setting of newly diagnosed, nonresectable cholangiocarcinoma. The second is a 64-year-old man with remote resection of cholangiocarcinoma who presented after routine laboratory monitoring showed significant AKI. Temporary dialysis was required in both cases before renal recovery occurred. Together, these cases should increase physicians' suspicion of AON in the presence of malabsorption. By doing so, the workup of oxalate nephropathy can be expedited with prompt initiation of treatment.
急性草酸盐肾病（AON）是急性肾损伤（AKI）日益被认识的病因。在此，我们报告两例经活检证实的急性草酸盐肾病患者，他们均有胃肠道吸收不良，巧合的是都源于胆管癌。第一例是一名73岁男性，因晕厥就诊，在新诊断为不可切除胆管癌的情况下被发现患有严重少尿型AKI。第二例是一名64岁男性，曾接受胆管癌切除术，在常规实验室检查显示有明显AKI后就诊。两例患者在肾功能恢复前均需要临时透析。总之，这些病例应增加医生在存在吸收不良时对AON的怀疑。这样做可以通过及时开始治疗加快草酸盐肾病的检查。
