Hong Yeon Hee, Han Soo Jin, Lee Dayong, Kim Seul Ki, Jee Byung Chul
Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.
Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea.
J Obstet Gynaecol Res. 2019 Apr;45(4):865-870. doi: 10.1111/jog.13917. Epub 2019 Jan 24.
To evaluate various adverse symptoms during short-term use of ulipristal acetate in women with uterine myomas (n = 90), adenomyosis (n = 3) or both (n = 7).
One hundred premenopausal women who received ulipristal acetate for 4-12 weeks during 2016 to 2017 were selected. The medical records were reviewed and the following information was collected; adverse symptoms during medication, presence of menorrhagia or menstrual cramps, blood hemoglobin and liver function test. Adverse symptoms were recorded in the medical records as a checklist form including 76 specific progestin-related symptoms.
Overall, the most frequent adverse symptom was amenorrhea (43%), followed by weight gain (29%), fatigue (27%), abdominal discomfort (21%), decreased menstrual flow (19%) and dizziness (18%). In 89 symptomatic women (with heavy menstrual bleeding and/or menstrual cramping pain and/or anemia), the most frequent adverse symptom was weight gain (27%) and fatigue (27%), followed by abdominal discomfort (21%), dry eye (18%), facial flushing (17%), dizziness (17%), headache (17%) and increased vaginal discharge (15%). Fourteen women stopped the medication due to unwanted adverse symptoms. Of this discontinuation group, major complaint was fatigue (50%), followed by weight gain (36%) and breast discomfort (35.7%).
Adverse symptoms were common and discontinuation rate was somewhat higher during short-term course of ulipristal acetate. Information about incidence of various adverse symptoms should be given to women who willing to take ulipristal acetate.
评估子宫肌瘤患者（n = 90）、子宫腺肌病患者（n = 3）或两者皆有的患者（n = 7）短期使用醋酸乌利司他期间的各种不良症状。
选取2016年至2017年期间接受醋酸乌利司他治疗4 - 12周的100名绝经前女性。查阅病历并收集以下信息：用药期间的不良症状、月经过多或痛经情况、血红蛋白及肝功能检查结果。不良症状以包含76种特定孕激素相关症状的清单形式记录在病历中。
总体而言，最常见的不良症状是闭经（43%），其次是体重增加（29%）、疲劳（27%）、腹部不适（21%）、月经量减少（19%）和头晕（18%）。在89名有症状的女性（有月经过多和/或痛经和/或贫血）中，最常见的不良症状是体重增加（27%）和疲劳（27%），其次是腹部不适（21%）、干眼（18%）、面部潮红（17%）、头晕（17%）、头痛（17%）和白带增多（15%）。14名女性因不良症状而停药。在这个停药组中，主要抱怨是疲劳（50%），其次是体重增加（36%）和乳房不适（35.7%）。
不良症状很常见，醋酸乌利司他短期疗程中的停药率有所升高。应向愿意服用醋酸乌利司他的女性提供各种不良症状发生率的信息。
