Ridwan-Pramana Angela, Idema Sander, Te Slaa Sjoerd, Verver Frank, Wolff Jan, Forouzanfar Tymour, Peerdeman Saskia
Department of Oral and Maxillofacial Surgery/Oral Pathology and 3D Innovation Lab.
Department of Maxillofacial Prosthodontics, Center for Special Care in Dentistry.
J Craniofac Surg. 2019 Mar/Apr;30(2):408-411. doi: 10.1097/SCS.0000000000005148.
Polymethyl methacrylate (PMMA), an easily moldable and economical synthetic resin, has been used since the 1940s. In addition, PMMA has good mechanical properties and is one of the most biocompatible alloplastic materials currently available. The PMMA can serve as a spacer and as a delivery vehicle for antibiotics. Prior studies have indicated that no significant differences in infection rates exist between autologous and acrylic cranioplasty. Although inexpensive, the free-hand cranioplasty technique often yields unsatisfactory cosmetic results. In the present study, the application of a recently developed, economic modality for the perioperative application, and molding of PMMA to ensure a precise fit in 16 patients using computer-aided design, computer-aided manufacturing, and rapid prototyping was described.The mean defect size was 102.0 ± 26.4 cm. The mean volume of PMMA required to perform the cranioplasty procedure was 51 mL. The cost of PMMA was approximately 6 Euro (&OV0556;) per mL. The costs of fabricating the implants varied from 119.8 &OV0556; to 1632.0 &OV0556; with a mean of 326.4 &OV0556; ± 371.6. None of the implants required removal during the follow-up period.
聚甲基丙烯酸甲酯（PMMA）是一种易于成型且经济的合成树脂，自20世纪40年代以来一直被使用。此外，PMMA具有良好的机械性能，是目前可用的生物相容性最佳的异质材料之一。PMMA可作为间隔物和抗生素的递送载体。先前的研究表明，自体颅骨成形术和丙烯酸颅骨成形术在感染率方面不存在显著差异。尽管徒手颅骨成形术成本低廉，但其美容效果往往不尽人意。在本研究中，描述了一种最近开发的经济模式在围手术期的应用，以及使用计算机辅助设计、计算机辅助制造和快速成型技术对PMMA进行成型以确保其在16例患者中精确适配的情况。平均缺损大小为102.0±26.4平方厘米。进行颅骨成形术所需的PMMA平均体积为51毫升。PMMA的成本约为每毫升6欧元（&OV0556;）。植入物的制造成本从119.8&OV0556;到1632.0&OV0556;不等，平均为326.4&OV0556;±371.6。在随访期间，没有植入物需要取出。
