Vale Fabiene, Rezende Camilla, Raciclan Alexon, Bretas Tancredo, Geber Selmo
Department of Obstetrics and Gynecology of the Universidade Federal de Minas Gerais, Av Contorno 7747, Belo Horizonte, Minas Gerais, Brazil.
Department of Obstetrics and Gynecology of the Universidade Federal de Minas Gerais, Av Contorno 7747, Belo Horizonte, Minas Gerais, Brazil.
Eur J Obstet Gynecol Reprod Biol. 2019 Mar;234:92-95. doi: 10.1016/j.ejogrb.2018.12.040. Epub 2019 Jan 11.
Evaluate the efficacy and safety of a non-hormonal intravaginal moisturizer on reducing the symptoms arising from vaginal dryness and sexual dysfunction.
A total of 37 postmenopausal women used a non-hormonal intravaginal Moisturizer (polycarbophil, butyl ester of a copolymer of methyl vinyl ether/ copolymer PVM/MA, 50% sodium lactate solution, and Carbopol) twice a week for 12 weeks. The vaginal moisture levels, volume of fluid, elasticity, and epithelium integrity were assessed using the Vaginal Health Index. Sexual function was measured using the Female Sexual Function Index questionnaire. All women were evaluated before starting treatment and at the 4th, 8th and 12th weeks of the study. At the end of the study, the patients analysed the treatment regarding to their satisfaction with the product, and its application system, their sense of well-being after using it as well as their perception bout the discharge of the moisturizer (if it run or was held by the vaginal mucosa).
There was a significant improvement in the vaginal moisture, fluid volume, elasticity and epithelial integrity (p < 0.001). Sexual function improved in the total score and in all six domains (p < 0.001). More than 50% of all patients reported being very satisfied with the treatment and product application. The sense of well-being was considered very good by 51.4% of the participants and most (91.9%) indicated that the product did not leak and did not stick to the vaginal mucosa. No severe adverse events were reported.
Our study suggests that treatment with the non-hormonal intravaginal moisturizer is a safe and efficient therapeutic option for the improvement of vaginal dryness with encouraging benefits for the sexual function of postmenopausal women.
评估一种非激素阴道保湿剂在减轻阴道干燥及性功能障碍相关症状方面的疗效和安全性。
37名绝经后女性每周两次使用一种非激素阴道保湿剂（聚卡波非、甲基乙烯基醚/马来酸酐共聚物的丁酯、50%乳酸钠溶液和卡波姆），持续12周。使用阴道健康指数评估阴道水分水平、液体量、弹性和上皮完整性。使用女性性功能指数问卷测量性功能。所有女性在开始治疗前以及研究的第4、8和12周接受评估。研究结束时，患者就其对产品及其应用系统的满意度、使用后的幸福感以及对保湿剂排出情况（是否流出或附着于阴道黏膜）的认知对治疗进行分析。
阴道水分、液体量、弹性和上皮完整性有显著改善（p < 0.001）。性功能在总分及所有六个领域均有改善（p < 0.001）。超过50%的患者报告对治疗和产品应用非常满意。51.4%的参与者认为幸福感非常好，大多数（91.9%）表示产品不渗漏且不附着于阴道黏膜。未报告严重不良事件。
我们的研究表明，使用非激素阴道保湿剂进行治疗是改善阴道干燥的一种安全有效的治疗选择，对绝经后女性的性功能有积极益处。
