铬酸盐暴露工人同源重组修复基因多态性对遗传损伤的调节。
Modulation of homologous recombination repair gene polymorphisms on genetic damage in chromate exposed workers.
机构信息
Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, 100191, PR China.
Department of Medical Record, Third Hospital of Peking University, Beijing, 100191, PR China.
出版信息
Environ Toxicol Pharmacol. 2019 Feb;66:126-132. doi: 10.1016/j.etap.2019.01.004. Epub 2019 Jan 16.
Hexavalent chromium [Cr(VI)] is one of the most common environmental carcinogens, which is associated with DNA damage, genetic instability and increase the risk of cancer development. However, the mechanisms of genetic damage induced by Cr(VI) remains to be thoroughly illustrated. A molecular epidemiological study was conducted on 120 chromate exposed workers and 97 controls. Results indicated that,the rs12432907 of XRCC3 carrying T allele, the rs144848 of BRCA2 with C allele and the rs1805800 of NBS1 with genotype(TT) of individuals were associated with lower genetic damage, while the rs2295152 of XRCC3 carrying T allele, the rs13312986 (CC and CT genotypes) and the rs2697679 of NBS1 with A allele were associated with higher genetic damage in workers exposed to chromate. The interaction of chromate exposure with rs2295152 of XRCC3 had a significant effect on micronuclei frequency (MNF). The gene polymorphisms in homologous recombination repair pathway could modulate chromate-induced genetic damage.
六价铬（Cr(VI)）是最常见的环境致癌物之一，与 DNA 损伤、遗传不稳定性和癌症发展风险增加有关。然而，Cr(VI)引起遗传损伤的机制仍需充分阐明。对 120 名铬酸盐暴露工人和 97 名对照进行了分子流行病学研究。结果表明，XRCC3 的 rs12432907 携带 T 等位基因、BRCA2 的 rs144848 携带 C 等位基因和 NBS1 的 rs1805800 携带基因型（TT）的个体与较低的遗传损伤有关，而 XRCC3 的 rs2295152 携带 T 等位基因、rs13312986（CC 和 CT 基因型）和 NBS1 的 rs2697679 携带 A 等位基因的个体与铬酸盐暴露工人的遗传损伤增加有关。铬酸盐暴露与 XRCC3 的 rs2295152 的相互作用对微核频率（MNF）有显著影响。同源重组修复途径中的基因多态性可调节铬酸盐引起的遗传损伤。
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