眼周肉毒毒素对泪膜稳态和眼表改变的综述。
A Review of Periocular Botulinum Neurotoxin on the Tear Film Homeostasis and the Ocular Surface Change.
机构信息
Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 33302, Taiwan.
Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
出版信息
Toxins (Basel). 2019 Jan 24;11(2):66. doi: 10.3390/toxins11020066.
Clinical usage of botulinum neurotoxin (BoNT) in ophthalmology has dramatically increased since the 1980s and has become one of the most widely used agents for treating facial movement disorders, autonomic dysfunction and aesthetic wrinkles. Despite its high efficacy, there are some complications with periocular BoNT injections due to its chemodenervation effect. Among these, there is still controversy over the BoNT effect on tear film homeostasis and the ocular surface. A periocular BoNT injection could dry the eye by reducing tear production of the lacrimal gland and increase tear evaporation due to potential eyelid malposition and abnormal blinks. On the contrary, the injection of BoNT in the medial eyelids could treat dry eye disease by impairing lacrimal drainage. Regarding the ocular surface change, corneal astigmatism and high-order aberrations may decrease due to less eyelid tension. In conclusion, the entire awareness of the effect of BoNT and the patients' ocular condition is crucial for successful and safe results.
自 20 世纪 80 年代以来，肉毒毒素（BoNT）在眼科的临床应用显著增加，已成为治疗面部运动障碍、自主神经功能障碍和美容皱纹最广泛使用的药物之一。尽管其疗效很高，但由于其化学去神经作用，眶周 BoNT 注射会引起一些并发症。其中，BoNT 对泪膜稳态和眼表的影响仍存在争议。眶周 BoNT 注射可能会因潜在的眼睑位置不正和异常眨眼而减少泪液分泌，增加泪液蒸发，从而使眼睛变干。相反，内侧眼睑注射 BoNT 可能会通过损害泪液引流来治疗干眼症。关于眼表的变化，由于眼睑张力降低，角膜散光和高阶像差可能会减小。总之，对 BoNT 作用的全面认识和患者的眼部状况对于获得成功和安全的结果至关重要。
Zotero 插件