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碳纤维增强聚合物-羟基磷灰石三元复合材料的简易合成:一种机械强度高的生物活性骨移植物。

Facile synthesis of carbon fiber reinforced polymer-hydroxyapatite ternary composite: A mechanically strong bioactive bone graft.

机构信息

Advanced Materials and Processes Division, CSIR-National Metallurgical Laboratory, Jamshedpur 831007, India; Department of Applied Chemistry, Indian Institute of Technology (Indian School of Mines), Dhanbad 826004, Jharkhand, India; Department of Chemistry, Mahila College, Kolhan University, Chaibasa 833201, Jharkhand, India.

Department of Applied Chemistry, Indian Institute of Technology (Indian School of Mines), Dhanbad 826004, Jharkhand, India.

出版信息

Mater Sci Eng C Mater Biol Appl. 2019 Apr;97:388-396. doi: 10.1016/j.msec.2018.12.064. Epub 2018 Dec 20.

Abstract

Carbon fiber reinforced carboxymethyl cellulose-hydroxyapatite ternary composites have been synthesized by a simple wet precipitation method for weight bearing orthopedic application. Composites were synthesized with the incorporation of chemically functionalized carbon fibers. The functional groups onto the surface of fibers induced the formation of hydroxyapatite at the bridging position through which fibers were effectively bound with matrix. Consequently, the flexural strength and compressive strength of composite have reached to 140 MPa and 118 MPa, respectively. The flexural modulus of the composite is in the range of 9-22 GPa. In-vitro cell study showed that the composite possesses excellent cell proliferation and differentiation ability. With these excellent mechanical and biological properties, synthesized composite exhibits potential to be used as a mechanically compatible bioactive bone graft.

摘要

碳纤维增强羧甲基纤维素-羟基磷灰石三元复合材料已通过简单的湿沉淀法合成,用于承重骨科应用。复合材料是通过化学官能化碳纤维的掺入合成的。纤维表面的官能团通过纤维与基体的有效结合,诱导桥位羟基磷灰石的形成。因此,复合材料的抗弯强度和抗压强度分别达到 140MPa 和 118MPa。复合材料的弯曲模量在 9-22GPa 范围内。体外细胞研究表明,该复合材料具有优异的细胞增殖和分化能力。具有这些优异的机械和生物学特性,合成的复合材料具有作为机械相容的生物活性骨移植物的潜力。

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