Núcleo de Neurociências, Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Programa de Pós-graduação em Engenharia Elétrica, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Sci Rep. 2019 Jan 24;9(1):473. doi: 10.1038/s41598-018-36871-6.
The absence of companion may jeopardize mental health in social animals. Here, we tested the hypothesis that social isolation impairs social recognition memory by altering the excitability and the dialog between the olfactory bulb (OB) and the dorsal hippocampus (dHIP). Adult male Swiss mice were kept grouped (GH) or isolated (SI) for 7 days. Social memory (LTM) was evaluated using social recognition test. SI increased glutamate release in the OB, while decreased in the dHIP. Blocking AMPA and NMDA receptors into the OB or activating AMPA into the dHIP rescued LTM in SI mice, suggesting a cause-effect relationship between glutamate levels and LTM impairment. Additionally, during memory retrieval, phase-amplitude coupling between OB and dHIP decreased in SI mice. Our results indicate that SI impaired the glutamatergic signaling and the normal communication between OB and HIP, compromising the persistence of social memory.
同伴的缺失可能会危及社交动物的心理健康。在这里，我们通过改变嗅球（OB）和背侧海马（dHIP）之间的兴奋性和对话来测试社交隔离会损害社交识别记忆的假设。成年雄性瑞士小鼠被分组（GH）或隔离（SI）饲养 7 天。使用社交识别测试评估社交记忆（LTM）。SI 增加了 OB 中的谷氨酸释放，而 dHIP 中的谷氨酸释放减少。OB 中 AMPA 和 NMDA 受体的阻断或 dHIP 中 AMPA 的激活可挽救 SI 小鼠的 LTM，表明谷氨酸水平与 LTM 损伤之间存在因果关系。此外，在记忆检索期间，SI 小鼠的 OB 和 dHIP 之间的相位-振幅耦合减少。我们的结果表明，SI 损害了 OB 和 HIP 之间的谷氨酸能信号传递和正常交流，从而损害了社交记忆的持久性。
