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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Lahera V, Cachofeiro V, Duran F, Cañizo F J, Rodriguez F J, Tresguerres J A

Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, Madrid, España.

Gen Pharmacol. 1988;19(6):835-9.

To investigate the possible effects of potassium canrenoate (PC) on plasma renin activity (PRA) and on renal prostaglandins (PGS) and kinins under elevated sodium and/or potassium intakes, a single dose of PC was administered to four groups of Wistar male rats. 2. They were fed a normal diet (C), a diet supplemented with 4% of NaCl, (Na), with 1% of KCl: (K) or both supplements (NaK). 3. PRA and urinary PGS excretion did not show changes after PC administration, but total urinary kinins showed higher values after the treatment in all groups. 4. A diuretic but not natriuretic effect was observed only in C animals. 5. In conclusion, the single dose of PC was able to stimulate urinary kinins and to spare potassium independently of dietary electrolyte supplements that were able to block the diuretic effect of the drug.

为研究在钠和/或钾摄入量增加的情况下，坎利酸钾（PC）对血浆肾素活性（PRA）、肾前列腺素（PGS）和激肽的可能影响，对四组雄性Wistar大鼠给予单剂量的PC。2. 它们分别喂食正常饮食（C组）、补充4%氯化钠的饮食（Na组）、补充1%氯化钾的饮食（K组）或同时补充两者的饮食（NaK组）。3. 给予PC后，PRA和尿PGS排泄未显示变化，但所有组治疗后尿激肽总量均显示较高值。4. 仅在C组动物中观察到利尿而非利钠作用。5. 总之，单剂量的PC能够刺激尿激肽并节省钾，且不受能够阻断该药物利尿作用的饮食电解质补充剂的影响。

Lahera V, Cachofeiro V, Duran F, Cañizo F J, Rodriguez F J, Tresguerres J A

Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, Madrid, España.

Gen Pharmacol. 1988;19(6):835-9.

To investigate the possible effects of potassium canrenoate (PC) on plasma renin activity (PRA) and on renal prostaglandins (PGS) and kinins under elevated sodium and/or potassium intakes, a single dose of PC was administered to four groups of Wistar male rats. 2. They were fed a normal diet (C), a diet supplemented with 4% of NaCl, (Na), with 1% of KCl: (K) or both supplements (NaK). 3. PRA and urinary PGS excretion did not show changes after PC administration, but total urinary kinins showed higher values after the treatment in all groups. 4. A diuretic but not natriuretic effect was observed only in C animals. 5. In conclusion, the single dose of PC was able to stimulate urinary kinins and to spare potassium independently of dietary electrolyte supplements that were able to block the diuretic effect of the drug.

为研究在钠和/或钾摄入量增加的情况下，坎利酸钾（PC）对血浆肾素活性（PRA）、肾前列腺素（PGS）和激肽的可能影响，对四组雄性Wistar大鼠给予单剂量的PC。2. 它们分别喂食正常饮食（C组）、补充4%氯化钠的饮食（Na组）、补充1%氯化钾的饮食（K组）或同时补充两者的饮食（NaK组）。3. 给予PC后，PRA和尿PGS排泄未显示变化，但所有组治疗后尿激肽总量均显示较高值。4. 仅在C组动物中观察到利尿而非利钠作用。5. 总之，单剂量的PC能够刺激尿激肽并节省钾，且不受能够阻断该药物利尿作用的饮食电解质补充剂的影响。