UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
Division of Geriatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Brain Behav Immun. 2019 May;78:143-152. doi: 10.1016/j.bbi.2019.01.016. Epub 2019 Jan 22.
In two cohorts, we aimed to establish associations between early-life adversities and adult inflammation, and whether adult (a) adiposity or (b) socioeconomic disadvantage are key intermediaries.
In both cohorts (N = 7661, 1958 British birth cohort; N = 1255, MIDUS), information was used on adult inflammatory markers (C-reactive protein (CRP), fibrinogen and (MIDUS only) interleukin-6 (IL-6)), adiposity and socioeconomic disadvantage, and early-life adversities (neglect, emotional neglect, physical, psychological, sexual abuse and childhood disadvantage).
Early-life adversities varied from 1.6% (sexual abuse, 1958 cohort) to 14.3% (socioeconomic disadvantage, MIDUS). Across the two cohorts, associations were consistent for physical abuse, e.g. 16.3%(3.01,29.7) and 17.0%(-16.4,50.3) higher CRP in the 1958 cohort and MIDUS respectively. Associations attenuated after accounting for adult adiposity, e.g. physical abuse (1958 cohort) and sexual abuse (MIDUS, non-white participants) associations were abolished. Some associations attenuated after adjustment for adult socioeconomic disadvantage; e.g. 1958 cohort neglect-CRP associations reduced from 23.2%(13.7,32.6) to 17.7%(8.18,27.2). Across the cohorts, no associations were found for psychological abuse or emotional neglect; associations for childhood socioeconomic disadvantage were inconsistent.
Specific early-life adversities are associated with adult inflammation; adiposity is a likely intermediary factor. Weight reduction and obesity prevention may offset pro-inflammatory related adult disease among those who experienced early-life adversities.
在两个队列中，我们旨在确定儿童早期逆境与成人炎症之间的关联，以及成人（a）肥胖或（b）社会经济劣势是否是关键的中介因素。
在两个队列中（N=7661，1958 年英国出生队列；N=1255，MIDUS），使用了成人炎症标志物（C 反应蛋白（CRP）、纤维蛋白原和（仅 MIDUS）白细胞介素-6（IL-6））、肥胖和社会经济劣势以及儿童早期逆境（忽视、情感忽视、身体、心理、性虐待和儿童劣势）的信息。
儿童早期逆境的比例从 1.6%（性虐待，1958 年队列）到 14.3%（社会经济劣势，MIDUS）不等。在两个队列中，身体虐待的关联是一致的，例如，在 1958 年队列中，CRP 分别升高 16.3%（3.01，29.7）和 17.0%（-16.4，50.3）。在考虑成人肥胖后，关联减弱，例如，身体虐待（1958 年队列）和性虐待（MIDUS，非白人参与者）的关联被消除。在调整成人社会经济劣势后，一些关联减弱；例如，1958 年队列中忽视-CRP 的关联从 23.2%（13.7，32.6）降至 17.7%（8.18，27.2）。在两个队列中，均未发现心理虐待或情感忽视的关联；儿童社会经济劣势的关联不一致。
特定的儿童早期逆境与成人炎症有关；肥胖可能是一个中介因素。减轻体重和预防肥胖可能会减轻那些经历过儿童早期逆境的人因炎症相关的成人疾病。
