Marioni Gino, Ottaviano Giancarlo, de Filippis Cosimo, Fasanaro Elena, Randon Benedetto, Meneghesso Stefano, Giacomelli Luciano, Astolfi Laura, Blandamura Stella
Department of Neuroscience DNS, Otolaryngology Section, University of Padova, Padova, Italy.
Department of Neuroscience DNS, Otolaryngology Section, University of Padova, Padova, Italy.
Am J Otolaryngol. 2019 Mar-Apr;40(2):224-229. doi: 10.1016/j.amjoto.2018.11.007. Epub 2018 Nov 22.
The main aim of the study was to preliminarily investigate the possibly related role of nuclear onco-suppressors maspin and nm23-H1, a metastasis suppressor, in laryngeal squamous cell carcinoma (LSCC).
Maspin expression pattern and nuclear nm23-H1 expression were ascertained in 62 consecutive LSCCs.
Recurrence rate was significantly lower in patients with a nuclear maspin pattern of expression; nuclear nm23-H1 expression was significantly lower in patients who experienced disease recurrence. Disease free survival (DFS) was significantly longer in patients with maspin nuclear pattern or with nuclear nm23-H1 expression ≥10%. A significant association was found between nuclear nm23-H1 expression and maspin pattern of expression in LSCC. KNN discriminant analysis considered N status, maspin sub-cellular localization and nuclear nm23-H1 expression. The selected variables' accuracy in terms of relapse was 82%. Positive predictive accuracy was 100%, and negative predictive accuracy 79%.
Nuclear nm23-H1 expression and maspin pattern, also in association, show promise as recurrence indicators in LSCC. Further studies are needed to shed more light on the nm23-H1 mechanism of action in LSCC and thus find ways to restore nm23-H1 loss. These preliminary findings suggest that re-activating maspin functions might represent an important goal in the treatment of advanced LSCC.
本研究的主要目的是初步探究核抑癌蛋白maspin和转移抑制因子nm23-H1在喉鳞状细胞癌（LSCC）中可能的相关作用。
在62例连续的LSCC病例中确定maspin的表达模式和核nm23-H1的表达情况。
核maspin表达模式的患者复发率显著较低；疾病复发的患者核nm23-H1表达显著较低。maspin呈核表达模式或核nm23-H1表达≥10%的患者无病生存期（DFS）显著更长。在LSCC中发现核nm23-H1表达与maspin表达模式之间存在显著关联。KNN判别分析考虑了N状态、maspin亚细胞定位和核nm23-H1表达。所选变量在复发方面的准确率为82%。阳性预测准确率为100%，阴性预测准确率为79%。
核nm23-H1表达和maspin表达模式，联合起来也有望成为LSCC的复发指标。需要进一步研究以更清楚地了解nm23-H1在LSCC中的作用机制，从而找到恢复nm23-H1缺失的方法。这些初步研究结果表明，恢复maspin功能可能是晚期LSCC治疗的一个重要目标。
