Sun Ya-Lei, Zheng Hai-Tao, Tao Jia-Lei, Jiang Ming-Chen, Hu Chan-Chan, Li Xin-Min, Yuan Bin
Affiliated Hospital of Nanjing University of Chinese Medicine, Department of Pediatrics, Nanjing, China.
Department of Integrated Chinese and Western Medicine, Henan University of Chinese Medicine, Zhengzhou, China.
Int J Pediatr Otorhinolaryngol. 2019 Apr;119:79-85. doi: 10.1016/j.ijporl.2019.01.022. Epub 2019 Jan 19.
Chinese herbal medicine has been gradually used to treat pediatric adenoid hypertrophy. This meta-analysis were conducted to evaluate the clinical efficacy and safety of Chinese herbal medicine in the treatment of pediatric adenoid hypertrophy.
Randomized controlled trials involving Chinese herbal medicine in the treatment of pediatric adenoid hypertrophy were identified from Cochrane Central Register of Controlled Trials, PubMed, EMBASE, Chinese National Knowledge Infrastructure, Chinese Biomedical Database, Wanfang Database and VIP Information Database. The methodological quality of trials was evaluated with Cochrane Handbook criteria, and the Cochrane Collaboration's Review Manager 5.3 software was used for Meta-analysis.
A total of 13 valid articles involving 1038 patients were included. The meta-analysis showed that: Compared with western medicine treatment, Chinese herbal medicine significantly improved clinical efficacy (RR = 1.33, 95% CI [1.24,1.43]), and significantly decreased A/N ratio (MD = -0.04,95%CI [-0.05,-0.03]). Chinese herbal medicine also prominently improved the quality of life (MD = -4.77,95%CI [-8.35,-1.20]). Meanwhile, it dramatically improved snoring (MD = -0.46,95%CI [-0.62,-0.30]); mouth breathing (MD = -0.52,95%CI [-0.66,-0.39]); nasal obstruction (MD = -0.56,95%CI [-0.68,-0.45]).
Chinese herbal medicine has good clinical efficacy and safety on pediatric adenoid hypertrophy, which need to be confirmed by high quality, multiple-centre, large sample randomized controlled trials.
中药已逐渐用于治疗小儿腺样体肥大。本荟萃分析旨在评估中药治疗小儿腺样体肥大的临床疗效和安全性。
从Cochrane对照试验中心注册库、PubMed、EMBASE、中国知网、中国生物医学数据库、万方数据库和维普资讯数据库中检索有关中药治疗小儿腺样体肥大的随机对照试验。采用Cochrane手册标准评估试验的方法学质量，并使用Cochrane协作网的RevMan 5.3软件进行荟萃分析。
共纳入13篇有效文章，涉及1038例患者。荟萃分析结果显示：与西药治疗相比，中药显著提高了临床疗效（RR = 1.33，95%CI [1.24,1.43]），并显著降低了A/N比值（MD = -0.04，95%CI [-0.05,-0.03]）。中药还显著改善了生活质量（MD = -4.77,95%CI [-8.35,-1.20]）。同时，显著改善了打鼾（MD = -0.46，95%CI [-0.62,-0.30]）、张口呼吸（MD = -0.52，95%CI [-0.66,-0.39]）和鼻塞（MD = -0.56，95%CI [-0.68,-0.45]）。
中药治疗小儿腺样体肥大具有良好的临床疗效和安全性，但需要高质量、多中心、大样本的随机对照试验加以证实。
