Numune Training and Research Hospital, Department of Otolaryngology, Ankara, Turkey.
Numune Training and Research Hospital, Department of Otolaryngology, Ankara, Turkey.
Am J Otolaryngol. 2019 May-Jun;40(3):347-352. doi: 10.1016/j.amjoto.2019.01.006. Epub 2019 Jan 20.
To compare the performance of Spongostan, Otopore, Spongostan soaked with dexamethasone and Spongostan soaked with Hyaluronic acid (HA) as middle ear packing material after mucosal trauma.
Twenty rats were divided into 4 groups. In control group (group 1), the middle ear cavities of animals were bilaterally packed with Spongostan; in group 2, with Otopore; in group 3, with Spongostan soaked with dexamethasone; and in group 4, with Spongostan soaked with HA. Auditory brainstem responses (ABRs) were performed preoperatively and 1 and 6 weeks postoperatively. Histological analyses were performed to evaluate the inflammatory reaction and wound healing in the middle ear cavity.
ABR recordings demonstrate that threshold level changes from baseline were minor in Otopore and Spongostan soaked with dexamethasone packed ears. Threshold levels were higher in the Spongostan and Spongostan soaked with HA packed ears compared with both Otopore and Spongostan soaked with dexamethasone packed ears. Histological analyses showed that Spongostan caused inflammation more intense than Otopore and Spongostan soaked with dexamethasone. Residual material at postoperative week 6, new bone formation and adhesion were common in the Spongostan group compared with other groups. Fibrosis was more common in Spongostan group compared with other groups but the difference was not significant.
Otopore appears to be safe and effective for use in otologic surgery. The inflammation, adhesion and new bone formation decreased when Spongostan was used with steroid or HA, when compared to Spongostan alone.
比较 Spongostan、Otopore、地塞米松浸泡的 Spongostan 和透明质酸（HA）浸泡的 Spongostan 作为中耳填塞材料在黏膜创伤后的性能。
将 20 只大鼠分为 4 组。在对照组（第 1 组）中，双侧中耳腔用 Spongostan 填塞；第 2 组用 Otopore；第 3 组用地塞米松浸泡的 Spongostan；第 4 组用透明质酸浸泡的 Spongostan。术前和术后 1 周、6 周进行听性脑干反应（ABR）测试。进行组织学分析以评估中耳腔的炎症反应和愈合情况。
ABR 记录显示，Otopore 和地塞米松浸泡的 Spongostan 填塞耳的阈值变化较基线轻微。与 Otopore 和地塞米松浸泡的 Spongostan 填塞耳相比，Spongostan 和透明质酸浸泡的 Spongostan 填塞耳的阈值水平更高。组织学分析表明，Spongostan 引起的炎症比 Otopore 和地塞米松浸泡的 Spongostan 更强烈。与其他组相比，术后第 6 周 Spongostan 组的残留材料、新骨形成和粘连更为常见。与其他组相比，Spongostan 组的纤维化更为常见，但差异无统计学意义。
Otopore 似乎是安全有效的耳科手术用材料。与单独使用 Spongostan 相比，当 Spongostan 与类固醇或 HA 一起使用时，炎症、粘连和新骨形成减少。
