a Medical Diagnostic Research Center , Jilin Province People's Hospital , Changchun , Jilin , China.
b School of Medicine , Changchun University of Chinese Medicine , Changchun , Jilin , China.
Adipocyte. 2019 Dec;8(1):77-82. doi: 10.1080/21623945.2019.1574194. Epub 2019 Feb 20.
Individual cell types vary enormously in the amount of different organelles they contain. One such organelle is the mitochondrion. Understanding how mitochondrial levels are controlled is essential since so many disease states seem to involve mitochondrial function. The beige adipocyte is an inducible form of adipocyte that emerges in response to cold exposure and some other external stimuli. To perform its thermogenic function, its level of mitochondria increases dramatically. If the stimuli are removed the mitochondrial levels return to base line. Following the withdrawal of external stimuli, beige adipocytes directly acquire a white fat-like phenotype through mitophagy-mediated mitochondrial degradation. The beige cell is therefore a dynamic model for studying the mechanism of mitochondrial biogenesis and degradation.
不同细胞类型所包含的细胞器数量差异巨大。线粒体就是这样一种细胞器。了解线粒体水平是如何控制的至关重要，因为许多疾病状态似乎都涉及线粒体功能。米色脂肪细胞是脂肪细胞的一种诱导形式，它会在受到寒冷刺激和其他一些外部刺激时出现。为了发挥其产热功能，其线粒体水平会显著增加。如果刺激被移除，线粒体水平会恢复到基线。在外部刺激被撤回后，米色脂肪细胞通过线粒体降解的细胞自噬直接获得类似于白色脂肪的表型。因此，米色细胞是研究线粒体生物发生和降解机制的动态模型。
