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别嘌醇与一名78岁痛风男性的意识丧失

Allopurinol and Loss of Consciousness in a 78-old Year Man Suffering from Gout.

作者信息

Arian Mahnaz, AkbariRad Mina, Moghaddam Ahmad Bagheri, Firoozi Abdollah, Jami Mohammad

机构信息

Department of Infectious Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Infect Disord Drug Targets. 2020;20(2):253-256. doi: 10.2174/1871526519666190128102039.

Abstract

Allopurinol is an FDA -Approved xanthine oxidase inhibitor, which is effective in the treatment of gout, hyperuricemia and uremic kidney stones in patients with an increased level of uric acid excretion. Xanthine oxidase acts by converting hypoxanthine and xanthine into uric acid, and therefore its inhibition results in decreased production of uric acid. The most common side effects of this medication are as follows: maculopapular rashes, hives, itching, headache, dizziness, abnormal hair loss, fever and hypersensitivity reaction. Case Presentation: This report represents a case of drug-induced meningitis of a senile man who ended up in the ICU due to the remarkably reduced state of consciousness.

摘要

别嘌醇是一种经美国食品药品监督管理局(FDA)批准的黄嘌呤氧化酶抑制剂,对尿酸排泄增加的患者治疗痛风、高尿酸血症和尿毒症肾结石有效。黄嘌呤氧化酶通过将次黄嘌呤和黄嘌呤转化为尿酸来发挥作用,因此对其的抑制会导致尿酸生成减少。这种药物最常见的副作用如下:斑丘疹、荨麻疹、瘙痒、头痛、头晕、异常脱发、发热和过敏反应。病例报告:本报告介绍了一名老年男性药物性脑膜炎病例,该患者因意识状态显著下降最终住进了重症监护病房(ICU)。

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