de Terlizzi M, Philip T, Toma M G, Colella R, Ceci A
Bone Marrow Transplant Unit, Centre Léon Bérard, Lyon, Francia.
Pediatr Med Chir. 1988 Jul-Aug;10(4):359-64.
The role of massive therapy followed by autologous bone marrow transplantation (ABMT) in pediatric tumours is reviewed. The rationale of such an approach based on dose-response relationship in clinical oncology, the usefulness of total body irradiation (TBI) as a part of conditioning regimens, and phase I and II trials with high dose drug combinations are discussed. The results of ABMT in lymphomas, sarcomas, neuroblastomas and other tumours are critically analyzed with special emphasis on prognostic factors, differences among conditioning regimens, intensive therapy morbidity and marrow purging procedures. Finally future perspectives and questions still unsolved are briefly summarized.
本文综述了大剂量治疗后自体骨髓移植（ABMT）在儿童肿瘤中的作用。讨论了基于临床肿瘤学剂量反应关系的这种治疗方法的理论依据、全身照射（TBI）作为预处理方案一部分的效用，以及高剂量联合用药的Ⅰ期和Ⅱ期试验。对ABMT在淋巴瘤、肉瘤、神经母细胞瘤和其他肿瘤中的结果进行了批判性分析，特别强调了预后因素、预处理方案之间的差异、强化治疗的发病率和骨髓净化程序。最后简要总结了未来的前景和尚未解决的问题。
