癌症与系统性硬化症之间的有趣关系：免疫系统和其他因素的作用。
Intriguing Relationships Between Cancer and Systemic Sclerosis: Role of the Immune System and Other Contributors.
机构信息
Medical School, Montpellier University, Montpellier, France.
Department of Internal Medicine-Multiorganic Diseases, Local Referral Center for Auto-immune Diseases, Saint-Eloi Hospital, Montpellier University, Montpellier, France.
出版信息
Front Immunol. 2019 Jan 10;9:3112. doi: 10.3389/fimmu.2018.03112. eCollection 2018.
Systemic sclerosis (SSc) is an autoimmune connective tissue disorder, characterized by multisystem involvement, vasculopathy, and fibrosis. An increased risk of malignancy is observed in SSc (including breast and lung cancers), and in a subgroup of patients with specific autoantibodies (i.e., anti-RNA polymerase III and related autoantibodies), SSc could be a paraneoplastic syndrome and might be directly related to an immune response against cancer. Herein, we reviewed the literature, focusing on the most recent articles, and shed light onto the potential relationship between cancer and scleroderma regarding temporal and immunological dimensions.
系统性硬化症（SSc）是一种自身免疫性结缔组织疾病，其特征为多系统受累、血管病变和纤维化。SSc 患者存在恶性肿瘤风险增加（包括乳腺癌和肺癌），并且在具有特定自身抗体的亚组患者中（即抗 RNA 聚合酶 III 及相关自身抗体），SSc 可能是副肿瘤综合征，并且可能与针对癌症的免疫反应直接相关。在此，我们复习了文献，重点关注最新文章，并阐明了癌症和硬皮病在时间和免疫学方面的潜在关系。
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