Al-Zakwani Ibrahim, M Mabry Ruth, Zubaid Mohammad, Alsheikh-Ali Alawi A, Almahmeed Wael, Shehab Abdullah, Rashed Wafa
Department of Pharmacology & Clinical Pharmacy, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman.
Office of the Regional Director, WHO Regional Office for the Eastern Mediterranean Region, Cairo, Egypt.
BMJ Glob Health. 2019 Jan 5;4(1):e001278. doi: 10.1136/bmjgh-2018-001278. eCollection 2019.
The objective of this study was to evaluate the association between education and major adverse cardiac events in patients with acute coronary syndrome (ACS) in the Arabian Gulf.
Data were analysed from 3874 consecutive patients diagnosed with ACS admitted to 29 hospitals in four Arabian Gulf countries from January 2012 to January 2013. Education was defined as any type of formal training from primary school and above. MACE included stroke/transient ischaemic attack (TIA), myocardial infarction (MI), all-cause mortality and readmissions for cardiac reasons.
The overall mean age was 60±13 years and 67% (n=2579) were men. A total of 53% (n=2039) of the patients had some form of school education. Adjusting for demographic and clinical characteristics as well as socioeconomic measures (insurance type and employment), at 12-month follow-up, educated patients were significantly less likely to have had MACE (adjusted OR (aOR): 0.55; 95% CI 0.44 to 0.68; p<0.001) than those with no formal education. The lower rate of events was also consistent across all MACE components: stroke/TIA (aOR: 0.56; 95% CI 0.33 to 0.94; p=0.030), MI (aOR: 0.58; 95% CI 0.38 to 0.86; p=0.008), all-cause mortality (aOR: 0.58; 95% CI 0.39 to 0.87; p=0.009) and readmissions for cardiac reasons (aOR: 0.61; 95% CI 0.48 to 0.77; p<0.001). MACE outcomes were consistent across men and women and across countries.
Education was associated with lower MACE events in patients with ACS in the Arabian Gulf. Interventions promoting healthy lifestyles and management of clinical risk factors for patients with low health literacy are urgently required.
本研究的目的是评估阿拉伯湾地区急性冠状动脉综合征(ACS)患者的教育程度与主要不良心脏事件之间的关联。
分析了2012年1月至2013年1月期间在阿拉伯湾四个国家的29家医院收治的3874例连续诊断为ACS的患者的数据。教育程度定义为从小学及以上的任何形式的正规培训。主要不良心脏事件包括中风/短暂性脑缺血发作(TIA)、心肌梗死(MI)、全因死亡率和因心脏原因再次入院。
总体平均年龄为60±13岁,67%(n = 2579)为男性。共有53%(n = 2039)的患者接受过某种形式的学校教育。在对人口统计学和临床特征以及社会经济指标(保险类型和就业情况)进行调整后,在12个月的随访中,受过教育的患者发生主要不良心脏事件的可能性显著低于未接受正规教育的患者(调整后的比值比(aOR):0.55;95%置信区间0.44至0.68;p<0.001)。在所有主要不良心脏事件组成部分中,事件发生率较低的情况也一致:中风/TIA(aOR:0.56;95%置信区间0.33至0.94;p = 0.030)、MI(aOR:0.58;95%置信区间0.38至0.86;p = 0.008)、全因死亡率(aOR:0.58;95%置信区间0.39至0.87;p = 0.009)和因心脏原因再次入院(aOR:0.61;95%置信区间0.48至0.77;p<0.001)。主要不良心脏事件的结果在男性和女性以及不同国家之间是一致的。
在阿拉伯湾地区,教育程度与ACS患者较低的主要不良心脏事件发生率相关。迫切需要针对健康素养较低的患者开展促进健康生活方式和管理临床风险因素的干预措施。