铱（III）催化2-（杂）芳基喹唑啉-4-酮骨架通过C-H键活化的炔基化反应
Iridium(III)-Catalyzed Alkynylation of 2-(Hetero)arylquinazolin-4-one Scaffolds via C-H Bond Activation.
作者信息
Rohokale Rajendra S, Kalshetti Rupali G, Ramana Chepuri V
机构信息
CSIR-National Chemical Laboratory , Division of Organic Chemistry , Dr. Homi Bhabha Road , Pune 411008 , India.
Academy of Scientific and Innovative Research , New Delhi 110025 , India.
出版信息
J Org Chem. 2019 Mar 1;84(5):2951-2961. doi: 10.1021/acs.joc.8b02738. Epub 2019 Feb 12.
The directed C-H alkynylation of 2-(hetero)arylquinazolin-4-ones has been explored with the ethynylbenziodoxolone reagent TIPS-EBX employing an Ir(III) catalyst. Complementary conditions for either monoalkynylation or dialkynylation have been developed. Also demonstrated is the broad scope of this reaction and the compatibility of various functional groups such as -F, -Cl, -Br, -CF, -OMe, -NO, and alkyl, etc.
利用铱（III）催化剂，使用乙炔基苯碘酰酮试剂TIPS-EBX对2-（杂）芳基喹唑啉-4-酮的定向C-H炔基化反应进行了探索。已开发出用于单炔基化或双炔基化的互补条件。还证明了该反应的广泛适用范围以及各种官能团（如-F、-Cl、-Br、-CF、-OMe、-NO和烷基等）的兼容性。
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