作为加纳城乡地区婴儿腹泻病因的致病性大肠杆菌和产肠毒素大肠杆菌

Enteropathogenic and enterotoxigenic Escherichia coli as aetiological factors of infantile diarrhoea in rural and urban Ghana.

作者信息

Agbodaze D, Abrahams C A, Arai S

机构信息

Noguchi Memorial Institute for Medical Research, University of Ghana, Legon.

出版信息

Trans R Soc Trop Med Hyg. 1988;82(3):489-91. doi: 10.1016/0035-9203(88)90173-3.

DOI:10.1016/0035-9203(88)90173-3

PMID:3068860

Abstract

There are 4 recognized classes of Escherichia coli that cause diarrhoeal disease in humans: enteropathogenic (EPEC), enterotoxigenic (ETEC), enteroinvasive (EIEC), and enterohaemorrhagic E. coli (EHEC). Preliminary analysis of enterotoxin production in a rural community in Ghana showed a prevalence of 11.0% LT-ST+, 9.5% LT+ST- and 7.5% EPEC. (LT = heat-labile, and ST = heat-stable, enterotoxin). The results of a similar study in an urban community in Accra, Ghana, showed 10.9% LT-ST+, 5.9% LT+ST-, 1.6% LT+ST+ and 6.5% EPEC. 14 different serotypes of EPEC were isolated in the urban area, whereas 6 serotypes and two untypable strains were isolated in the rural area. The most common serotype isolated in Accra was 0126:K71 and that from the rural area was 0128:K67. Serotypes 0143:KXI and 0155:K59 are reported for the first time in Ghana.

摘要

已知有4类大肠杆菌可导致人类腹泻疾病：肠致病性大肠杆菌（EPEC）、产肠毒素性大肠杆菌（ETEC）、肠侵袭性大肠杆菌（EIEC）和肠出血性大肠杆菌（EHEC）。对加纳一个农村社区的肠毒素产生情况进行的初步分析显示，产热不稳定和热稳定肠毒素（LT-ST+）的患病率为11.0%，产热不稳定肠毒素（LT+ST-）为9.5%，肠致病性大肠杆菌（EPEC）为7.5%。（LT = 热不稳定，ST = 热稳定，肠毒素）。在加纳阿克拉一个城市社区进行的类似研究结果显示，LT-ST+为10.9%，LT+ST-为5.9%，LT+ST+为1.6%，EPEC为6.5%。在城市地区分离出14种不同血清型的EPEC，而在农村地区分离出6种血清型和两株无法分型的菌株。在阿克拉分离出的最常见血清型是0126:K71，农村地区是0128:K67。血清型0143:KXI和0155:K59在加纳首次报道。