From the Department of Neurosurgery and Cyclotron Research Center, Iwate Medical University, Morioka, Japan.
Clin Nucl Med. 2019 Apr;44(4):295-296. doi: 10.1097/RLU.0000000000002469.
A 48-year-old man experienced recurrent vertigo refractory to antiplatelet medications. Cerebral angiography showed occlusion of bilateral vertebral arteries with poor collateral circulation. PET using O2 gas showed reduced blood flow and metabolic rate of oxygen and elevated oxygen extraction fraction in bilateral cerebellar hemispheres. Subsequent F-FRP170 (1-(2-F-fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole) PET, which depicts hypoxic but viable tissue, revealed elevated tracer uptake in the same regions. After superficial temporal artery-posterior cerebral artery anastomosis, O-gas PET showed normalization of blood flow, metabolic rate of oxygen, and oxygen extraction fraction in bilateral cerebellar hemispheres. Abnormally elevated F-FRP-170 uptake was also resolved in those regions.
一位 48 岁男性患者反复发作的眩晕，对抗血小板药物治疗无效。脑血管造影显示双侧椎动脉闭塞，侧支循环不良。O2 气体 PET 显示双侧小脑半球的血流和氧代谢率降低，氧摄取分数升高。随后进行的 F-FRP170（1-（2-F-氟-1-（羟甲基）乙氧基）甲基-2-硝基咪唑）PET 显示低氧但存活的组织，显示相同区域摄取示踪剂增加。行颞浅动脉-大脑后动脉吻合术后，O2 气体 PET 显示双侧小脑半球的血流、氧代谢率和氧摄取分数恢复正常。这些区域的 F-FRP-170 摄取异常也得到了纠正。
