68Ga-PSMA-11 PET/MR 在正常前列腺组织中可能呈假阳性。
68Ga-PSMA-11 PET/MR Can Be False Positive in Normal Prostatic Tissue.
机构信息
Department of Nuclear Medicine, University Hospital Zürich, University of Zürich
Department of Pathology and Molecular Pathology, University Hospital and University of Zürich
出版信息
Clin Nucl Med. 2019 Apr;44(4):e291-e293. doi: 10.1097/RLU.0000000000002473.
Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein expressed in the cytosol of normal prostate tissue and highly overexpressed on the membrane of prostate cancer, therefore increasingly used to image prostate cancer. We report a case of a 65-year-old man with two focal PSMA-positive areas on a Ga-PSMA-11 PET/MR, one corresponding to a prostate carcinoma (Gleason score 4 + 3) and another region without any evidence of malignancy, but with corresponding high PSMA-expression on immunohistochemistry.
前列腺特异性膜抗原（PSMA）是一种跨膜糖蛋白，在正常前列腺组织的细胞质中表达，在前列腺癌的膜上高度过表达，因此越来越多地用于前列腺癌的成像。我们报告了一例 65 岁男性，在 Ga-PSMA-11 PET/MR 上有两个局灶性 PSMA 阳性区域，一个区域对应前列腺癌（Gleason 评分 4+3），另一个区域没有任何恶性证据，但免疫组化显示 PSMA 表达较高。
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