Baskiran Adil, Sahin Emrah, Karadag Nese, Sahin Tevfik Tolga, Barut Bora, Ozgor Dincer, Dirican Abuzer
Department of Surgery, Inonu University Institute of Liver Transplantation, Malatya, Turkey.
Department of Pathology, Inonu University, Malatya, Turkey.
North Clin Istanb. 2018 Sep;5(3):195-198. doi: 10.14744/nci.2017.69320.
Gallbladder cancer (GBC) is a rare clinical entity that has a poor prognosis. Radical resection with meticulous lymph node dissection is the only treatment option. The aim of the present study is to evaluate the efficacy of radical resection for GBC in the early postoperative period with the viewpoint of clinicopathological correlation.
Patients (n=24) who underwent radical resection with lymph node dissection for GBC between 2015 and 2017 were included. Demographic data, histopathologic tumor type, preoperative tumor markers, pathologic tumor size/stage (depth of invasion), lymph node metastasis and metastasis rates, and postoperative early mortality were evaluated. The patients were grouped in two groups according to lymph node metastases: Group 1 (without lymph node metastasis) and Group 2 (with lymph node metastasis).
The median age of the patients in Group 1 and Group 2 was 65 (range, 42-89) years and 68 (range, 48-87) years, respectively (p>0.05). The female/male ratio in Group 1 and Group 2 was 4/4 and 13/3, respectively (p>0.05). There was a tendency for increased metastasis in Group 2 compared with Group 1 (31% vs. 0%) (p>0.05). Also, 88% of the tumors in Group 2 were in the advanced stage, whereas the rate was 37% in Group 1 (p<0.05). There was early postoperative mortality in seven patients who underwent resection. Four of the seven patients (43%) were from Group 2 and three (37%) from Group 1 (p>0.05).
Lymph node metastasis in GBC indicates advanced tumor stage. This causes a more complex surgical resection and therefore results in higher early postoperative mortality.
胆囊癌（GBC）是一种临床罕见实体，预后较差。根治性切除并细致清扫淋巴结是唯一的治疗选择。本研究旨在从临床病理相关性角度评估GBC根治性切除在术后早期的疗效。
纳入2015年至2017年间接受GBC根治性切除并清扫淋巴结的患者（n = 24）。评估人口统计学数据、组织病理学肿瘤类型、术前肿瘤标志物、病理肿瘤大小/分期（浸润深度）、淋巴结转移及转移率，以及术后早期死亡率。根据淋巴结转移情况将患者分为两组：第1组（无淋巴结转移）和第2组（有淋巴结转移）。
第1组和第2组患者的中位年龄分别为65岁（范围42 - 89岁）和68岁（范围48 - 87岁）（p>0.05）。第1组和第2组的女性/男性比例分别为4/4和13/3（p>0.05）。与第1组相比，第2组有转移增加的趋势（31%对0%）（p>0.05）。此外，第2组88%的肿瘤处于晚期，而第1组这一比例为37%（p<0.05）。接受切除的7例患者出现术后早期死亡。7例患者中有4例（43%）来自第2组，3例（37%）来自第1组（p>0.05）。
GBC中的淋巴结转移表明肿瘤分期较晚。这导致手术切除更为复杂，从而导致更高的术后早期死亡率。
