Vara-Thorbeck R, Rosell J, Salvi M, Vara-Thorbeck C
Chirurgischen Klinik, Universität Granada.
Zentralbl Chir. 1988;113(18):1204-9.
The effectiveness of heparin DHE and preoperative haemodilution (M.N.H.) for prophylaxis against deep venous thrombosis (D.V.T.) and against early septic complications was investigated in a prospective controlled study on two comparable groups of patients who had undergone colorectal resections for malignant tumours. The results clearly suggested that there was no significant difference between heparin DHE and preoperative haemodilution for prophylactic effectiveness on D.V.T. yet, the percentage of postoperative septic early complications, that is insufficiency of anastomosis and abdominal wall infections, was much lower (p less than 0.001) in patients with moderate normovolaemic haemodilution (haematocrit = 30 per cent). While the number of cases reviewed was as low as 62, the point can be made that less postoperative septic complications occurred to patients with low haematocrit (30 per cent).
在一项针对两组因恶性肿瘤接受结直肠切除术的可比患者进行的前瞻性对照研究中，研究了肝素二氢麦角碱（DHE）和术前血液稀释（M.N.H.）预防深静脉血栓形成（D.V.T.）和早期感染并发症的有效性。结果清楚地表明，肝素DHE和术前血液稀释在预防D.V.T.的有效性方面没有显著差异，然而，在中度正常血容量血液稀释（血细胞比容 = 30%）的患者中，术后早期感染并发症的发生率，即吻合口功能不全和腹壁感染的发生率要低得多（p < 0.001）。虽然所审查的病例数低至62例，但可以指出的是，血细胞比容低（30%）的患者术后感染并发症较少。
