[结直肠癌肝转移的射频消融治疗]

[Radiofrequency Ablation for Colorectal Liver Metastases].

作者信息

Nakajima Takayoshi, Aihara Tsukasa, Ikuta Shinichi, Kusunoki Kurando, Akatsuka Masako, Kitamura Yu, Mitsufuji Suguru, Ichise Noriko, Hamano Ikumi, Okamoto Ryo, Nakamoto Yoshihiko, Kimura Fumihiko, Yanagi Hidenori, Yamanaka Naoki

机构信息

Dept. of Surgery, Meiwa Hospital.

出版信息

Gan To Kagaku Ryoho. 2018 Dec;45(13):1791-1793.

PMID:30692355

Abstract

AIM

The significance of radiofrequency ablation(RFA)for colorectal liver metastases(CRLM)remains to be elucidated. Therefore, this retrospective study aimed to evaluate the therapeutic efficacy of RFA for local recurrence of CRLM.

SUBJECTS

Between June 2005 and June 2017, we retrospectively examined 63 patients(137 nodules)with CRLM who underwent RFA.

RESULTS

The local recurrence rate was 36.5%, and the median local recurrence free survival(LRFS)was 26.3 months. We compared treatment background between the 2 groups with(50 nodules)and without(87 nodules)local recurrence. In the multivariate analysis, tumor size of the ablated lesion and method for ablation(direct tumor puncture)were independent risk factors for local recurrence. Receiver operating characteristic curve for tumor size of the ablated lesion showed an optimal cutoff value for tumor size of 1.8 cm(AUC=0.734, 95%CI: 0.612-0.855, p<0.0001).

CONCLUSIONS

RFA for effective control of local recurrence of CRLM might be suitable for selected patients with tumor size of ablated lesion ofC1.8 cm and no touch ablation method.

摘要

目的

射频消融术（RFA）治疗结直肠癌肝转移（CRLM）的意义仍有待阐明。因此，本回顾性研究旨在评估RFA对CRLM局部复发的治疗效果。

研究对象

2005年6月至2017年6月期间，我们回顾性研究了63例接受RFA治疗的CRLM患者（137个结节）。

结果

局部复发率为36.5%，局部无复发生存期（LRFS）的中位数为26.3个月。我们比较了有局部复发（50个结节）和无局部复发（87个结节）两组的治疗背景。多因素分析显示，消融病灶的肿瘤大小和消融方法（直接肿瘤穿刺）是局部复发的独立危险因素。消融病灶肿瘤大小的受试者工作特征曲线显示，肿瘤大小的最佳截断值为1.8 cm（AUC=0.734，95%CI：0.612-0.855，p<0.0001）。