Mehra Ruhi A, Gupta Seema A, Borkar D B
Department of Immunohematology and Blood Transfusion, MGM Medical College and Hospital, Mumbai, Maharashtra, India.
Asian J Transfus Sci. 2018 Jul-Dec;12(2):157-159. doi: 10.4103/ajts.AJTS_128_16.
Sickle cell-beta thalassemia is a double heterozygous state. Red cell exchange (RCE) transfusion reduces the concentration of sickle cells without increasing the hematocrit or whole-blood viscosity. It can be performed manually or by erythrocytapheresis. RCE transfusion is an effective tool for both acute and chronic complications of sickle cell disease. In patients unaffording erythrocytapheresis, even manual RCE can give favorable results. A 37-year-old male, a known case of sickle cell-beta thalassemia (ββ+), presented with avascular necrosis of right femur and humeral head. He was posted for the right hip arthroplasty and shoulder hemiarthroplasty. Successful manual RCE transfusions were done. The hemoglobin S levels decreased postmanual RCE procedures, and the patient was operated successfully.
镰状细胞-β地中海贫血是一种双重杂合状态。红细胞置换（RCE）输血可降低镰状细胞的浓度，而不会增加血细胞比容或全血粘度。它可以手动进行，也可以通过红细胞单采术进行。RCE输血是治疗镰状细胞病急性和慢性并发症的有效工具。对于负担不起红细胞单采术的患者，即使是手动RCE也能取得良好效果。一名37岁男性，已知患有镰状细胞-β地中海贫血（ββ+），出现右股骨和肱骨头缺血性坏死。他被安排进行右髋关节置换术和肩关节半关节置换术。成功进行了手动RCE输血。手动RCE操作后血红蛋白S水平下降，患者手术成功。
