Vose J M, Armitage J O, Duggan M, Braddock S W
Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68105-1065.
Cutis. 1988 Oct;42(4):335-7.
Pyoderma gangrenosum is frequently associated with an underlying condition such as ulcerative colitis or a myeloproliferative syndrome. However, lymphoproliferative malignancies have only rarely been seen concurrently with pyoderma gangrenosum. We present the case of a patient with small lymphocytic lymphoma who noted a slowly enlarging skin ulcer that was clinically consistent with pyoderma gangrenosum. Examination of a biopsy specimen showed infiltration of the skin with lymphoma cells as well as deeper necrotic material and thrombosis of vessels that were infiltrated by lymphoma. This case illustrates the difficulty of differentiating pyoderma gangrenosum from cutaneous lymphoma clinically.
坏疽性脓皮病常与潜在疾病相关，如溃疡性结肠炎或骨髓增殖综合征。然而，淋巴增殖性恶性肿瘤很少与坏疽性脓皮病同时出现。我们报告一例小淋巴细胞淋巴瘤患者，该患者发现一处皮肤溃疡缓慢增大，临床症状与坏疽性脓皮病相符。活检标本检查显示皮肤有淋巴瘤细胞浸润，以及更深层的坏死物质和被淋巴瘤浸润的血管血栓形成。该病例说明了临床上区分坏疽性脓皮病与皮肤淋巴瘤的困难。
