Mainville Gisele N
Department of Stomatology, Faculty of Dental Medicine, Université de Montréal Montreal, Centre-ville station, PO Box 6128, Montreal, QC, H3C 3J7, Canada.
Head Neck Pathol. 2019 Mar;13(1):71-79. doi: 10.1007/s12105-019-01001-9. Epub 2019 Jan 29.
Excluding human papillomavirus (HPV)-driven conditions, oral papillary lesions consist of a variety of reactive and neoplastic conditions and, on occasion, can herald internal malignancy or be part of a syndrome. The objectives of this paper are to review the clinical and histopathological features of the most commonly encountered non-HPV papillary conditions of the oral mucosa. These include normal anatomic structures (retrocuspid papillae, lingual tonsils), reactive lesions (hairy tongue, inflammatory papillary hyperplasia), neoplastic lesions (giant cell fibroma), lesions of unknown pathogenesis (verruciform xanthoma, spongiotic gingival hyperplasia) and others associated with syndromes (for instance Cowden syndrome) or representing paraneoplastic conditions (malignant acanthosis nigricans). Common questions regarding differential diagnosis, management, and diagnostic pitfalls are addressed, stressing the importance of clinico-pathologic correlation and collaboration.
排除由人乳头瘤病毒（HPV）引发的病症，口腔乳头状病变包括多种反应性和肿瘤性病症，有时可预示体内恶性肿瘤或成为某种综合征的一部分。本文的目的是回顾口腔黏膜最常见的非HPV乳头状病症的临床和组织病理学特征。这些病症包括正常解剖结构（龈后乳头、舌扁桃体）、反应性病变（毛舌、炎性乳头状增生）、肿瘤性病变（巨细胞纤维瘤）、发病机制不明的病变（疣状黄瘤、海绵状牙龈增生）以及与综合征相关的其他病变（如考登综合征）或副肿瘤性病症（恶性黑棘皮病）。文中探讨了关于鉴别诊断、管理和诊断陷阱的常见问题，强调了临床病理相关性和协作的重要性。
