Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
NMR Biomed. 2019 Oct;32(10):e4053. doi: 10.1002/nbm.4053. Epub 2019 Jan 28.
Because of the spatial and temporal heterogeneities of cancers, technologies to investigate cancer cells and the consequences of their interactions with abnormal physiological environments, such as hypoxia and acidic extracellular pH, with stromal cells, and with the extracellular matrix, under controlled conditions, are valuable to gain insights into the functioning of cancers. These insights can lead to an understanding of why cancers invade and metastasize, and identify effective treatment strategies. Here we have provided an overview of the applications of MRI/MRS/MRSI to investigate intact perfused cancer cells, their metabolism and invasion, and their interactions with stromal cells and the extracellular matrix.
由于癌症在空间和时间上存在异质性，因此，在控制条件下研究癌症细胞及其与异常生理环境（如缺氧和酸性细胞外 pH 值）、基质细胞以及细胞外基质相互作用的后果的技术，对于深入了解癌症的功能是有价值的。这些见解可以帮助我们了解癌症为什么会侵袭和转移，并确定有效的治疗策略。在这里，我们提供了一个综述，介绍了 MRI/MRS/MRSI 在研究完整灌注的癌细胞、它们的代谢和侵袭以及它们与基质细胞和细胞外基质的相互作用方面的应用。
