基于循环中性粒细胞的胸部肿瘤放射敏感性列线图。
Radiosensitivity nomogram based on circulating neutrophils in thoracic cancer.
机构信息
Department of Radiation Oncology, Qianfoshan Hospital affiliated to Shandong University, Shandong University, 16766 Jingshi Road, Jinan, 250014, PR China.
Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Collaborative Innovation Center of Cancer Medicine, Fudan University Shanghai Cancer Center, Shanghai, 200030, PR China.
出版信息
Future Oncol. 2019 Mar;15(7):727-737. doi: 10.2217/fon-2018-0398. Epub 2019 Jan 29.
AIM
To evaluate the prediction ability of neutrophils and develop a nomogram on radiosensitivity in thoracic cancer patients.
METHODS
We retrospectively reviewed 398 lung and esophageal cancers patients who received external-beam radiotherapy or concurrent chemoradiotherapy as first-line therapy.
RESULTS
Logistic regression model showed that patients with low levels of neutrophil counts and/or TGF-β1 exhibited better radiation sensitivity. Furthermore, a nomogram was created to predict radiotherapy sensitivity. The combination of neutrophil count and TGF-β1 level was an independent prognostic factor for lung and esophageal cancers patients.
CONCLUSION
The study developed a nomogram based on the levels of circulating neutrophils and TGF-β1. The prediction value in radiosensitivity and protumorigenic effect of neutrophils might owe to N2 tumor-associated neutrophils.
目的
评估中性粒细胞对胸癌患者放射敏感性的预测能力，并构建相关列线图。
方法
回顾性分析 398 例接受外照射或同步放化疗的肺癌和食管癌患者。
结果
Logistic 回归模型显示，中性粒细胞计数和/或 TGF-β1 水平低的患者具有更好的放射敏感性。进一步构建了预测放疗敏感性的列线图。中性粒细胞计数和 TGF-β1 水平的联合是肺癌和食管癌患者的独立预后因素。
结论
本研究基于循环中性粒细胞和 TGF-β1 水平建立了一个列线图。中性粒细胞的放射敏感性和促肿瘤效应的预测价值可能归因于 N2 肿瘤相关中性粒细胞。
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