Mogensen C E
Second University Clinic of Internal Medicine, Kommunehospitalet, Aarhus, Denmark.
Diabetes Care. 1988 Nov-Dec;11 Suppl 1:10-5.
The pathophysiology of diabetic renal disease has been greatly clarified in recent years. A better understanding of its developmental stages has led to a series of therapeutic intervention trials. I describe the natural history of untreated insulin-dependent diabetes mellitus (IDDM) and the effects of various intervention modalities. Selected trials, some of them still in progress, are summarized, including studies of therapy with insulin, antihypertensives, and low-protein diets.
近年来，糖尿病肾病的病理生理学已得到极大阐明。对其发展阶段的更深入了解引发了一系列治疗干预试验。我将描述未经治疗的胰岛素依赖型糖尿病（IDDM）的自然病程以及各种干预方式的效果。总结了一些已选试验，其中一些仍在进行中，包括胰岛素、抗高血压药物和低蛋白饮食治疗的研究。
