（18F）FDG PET/CT与（68Ga）DOTATATE PET/CT成像方法在检测肺类癌肿瘤患者组织学亚型及相关SUVmax值方面的比较

Comparison of (18F)FDG PET/CT and (68Ga)DOTATATE PET/CT imaging methods in terms of detection of histological subtype and related SUVmax values in patients with pulmonary carcinoid tumors.

作者信息

Komek Halil, Can Canan, Urakçi Zuhat, Kepenek Ferat

机构信息

Department of Nuclear Medicine, Diyarbakir Gazi Yasargil Training and Research Hospital.

Department of Medical Oncology, Faculty of Medical, University of Dicle, Diyarbakir, Turkey.

出版信息

Nucl Med Commun. 2019 May;40(5):517-524. doi: 10.1097/MNM.0000000000000985.

DOI:10.1097/MNM.0000000000000985

PMID:30694875

Abstract

OBJECTIVE

This study was designed to compare the 18-Fluorodeoxyglucose positron emission tomography/computed tomography [(F)FDG PET/CT] and 1,4,7,10-tetraazacyclododecane-NI,NII,NIII,NIIII-tetraacetic acid (D)-Phe1-thy3-octreotate [(Ga)DOTATATE PET/CT) findings in patients with pulmonary carcinoid (PC) tumors.

MATERIALS AND METHODS

A total of 20 patients [mean (SD) age: 52.2 (12.9) years, 60% women] with PC tumors and available records on digital images of (F)FDG PET/CT and (Ga)DOTATATE PET/CT and histopathological analysis were included in this retrospective single-center study. Patient characteristics, structural and functional imaging, and final histopathology were recorded in all patients. Typical and atypical PC tumors were compared in terms of patient age, tumor site, tumor size, and SUV max values obtained by (F)FDG PET/CT and (Ga)DOTATATE PET/CT imaging.

RESULTS

Overall, median (minimum-maximum) SUVmax values were 3.2 (1.2-11.2) in (F)FDG PET/CT and 17.2 (2.5-89.0) in (Ga)DOTATATE PET/CT. Atypical PC tumor was associated with significantly higher mean±SD age (64.6±5.4 vs. 45.5±10.5 years, P=0.036) and median (minimum-maximum) (F)FDG PET/CT SUVmax values [7.3 (4.8-11.2) vs. 2.4 (1.2-3.9), P=0.003], but with significantly lower median (minimum-maximum) (Ga)DOTATATE PET/CT SUVmax values [6.4 (2.5-10.6) vs. 23.7 (14.2-89), P<0.001], compared with typical PC tumor. (F)FDG PET/CT and (Ga)DOTATATE PET/CT SUVmax values were negatively correlated (r=-0.429, P=0.011).

CONCLUSION

Our findings in patients with histologically proven PC tumors showed higher SUV max values for (F)FDG PET/CT in atypical PC tumors and for (Ga)DOTATATE PET/CT in typical PC tumors. Our findings indicate the likelihood of higher detection rates particularly for typical PC tumors by (Ga)DOTATATE PET/CT imaging and the potential utility of the SUVmax ratio in predicting the histological subtype of PC tumors.

摘要

目的

本研究旨在比较18氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描[（F）FDG PET/CT]与1,4,7,10-四氮杂环十二烷-NI,NII,NIII,NIIII-四乙酸（D）-苯丙氨酸1-酪胺酸3-奥曲肽[（Ga）DOTATATE PET/CT]在肺类癌（PC）肿瘤患者中的检查结果。

材料与方法

本回顾性单中心研究纳入了20例PC肿瘤患者[平均（标准差）年龄：52.2（12.9）岁，60%为女性]，这些患者有（F）FDG PET/CT和（Ga）DOTATATE PET/CT的数字图像记录以及组织病理学分析结果。记录了所有患者的特征、结构和功能成像以及最终的组织病理学情况。对典型和非典型PC肿瘤在患者年龄、肿瘤部位、肿瘤大小以及通过（F）FDG PET/CT和（Ga）DOTATATE PET/CT成像获得的SUV最大值方面进行了比较。

结果

总体而言，（F）FDG PET/CT的SUVmax中位数（最小值-最大值）为3.2（1.2-11.2），（Ga）DOTATATE PET/CT的为17.2（2.5-89.0）。与典型PC肿瘤相比，非典型PC肿瘤的平均±标准差年龄显著更高（64.6±5.4岁对45.5±10.5岁，P=0.036），（F）FDG PET/CT的SUVmax中位数（最小值-最大值）也显著更高[7.3（4.8-11.2）对2.4（1.2-3.9），P=0.003]，但（Ga）DOTATATE PET/CT的SUVmax中位数（最小值-最大值）显著更低[6.4（2.5-10.6）对23.7（14.2-89），P<0.001]。（F）FDG PET/CT和（Ga）DOTATATE PET/CT的SUVmax值呈负相关（r=-0.429，P=0.011）。

结论

我们在组织学确诊的PC肿瘤患者中的研究结果显示，非典型PC肿瘤中（F）FDG PET/CT的SUV最大值较高，而典型PC肿瘤中（Ga）DOTATATE PET/CT的SUV最大值较高。我们的研究结果表明，（Ga）DOTATATE PET/CT成像尤其对于典型PC肿瘤有更高的检出率可能性，并且SUVmax比值在预测PC肿瘤的组织学亚型方面具有潜在应用价值。