Sumarokov D D, Gutkin D V
Farmakol Toksikol. 1988 Nov-Dec;51(6):73-6.
The effects of steroid (dexamethasone) and nonsteroid (indomethacin) anti-inflammatory drugs on the composition and the osteoinductive activity of bone tissue were studied on rats. Dexamethasone was found to induce bone tissue demineralisation and dose-dependent suppression of the osteoinductive activity, i.e. the ability to cause ectopic osteogenesis. Indomethacin, on the contrary, increases the osteoinductive activity of bone tissue. The findings are suggested to be due to different effect of steroid and nonsteroid anti-inflammatory drugs on the synthesis of prostaglandins and leukotrienes.
在大鼠身上研究了类固醇（地塞米松）和非类固醇（吲哚美辛）抗炎药对骨组织成分和骨诱导活性的影响。发现地塞米松会诱导骨组织脱矿，并呈剂量依赖性抑制骨诱导活性，即引起异位骨生成的能力。相反，吲哚美辛会增加骨组织的骨诱导活性。这些发现表明是由于类固醇和非类固醇抗炎药对前列腺素和白三烯合成的不同作用所致。
