van Uem J F, Hodgen G D
Klinik für Frauenheilkunde und Poliklinik der Universität Erlangen-Nürnberg.
Geburtshilfe Frauenheilkd. 1988 Dec;48(12):829-34. doi: 10.1055/s-2008-1026636.
Recently potent 19-norprogestin derivatives of the RU 486-type were developed. Acting at the receptor level, these steroids are considered a major breakthrough in steroid endocrinology. Clinical studies indicate their potential use in fertility control. Besides biochemical, pharmacological and clinical aspects of the antiprogestins, the ultimate role in the therapeutic management of certain endometrial and breast cancers, endometriosis as well as induction of labour at term are discussed.
最近开发出了RU 486型强效19-去甲孕酮衍生物。这些甾体在受体水平起作用，被认为是甾体内分泌学的一项重大突破。临床研究表明它们在生育控制方面有潜在用途。除了抗孕激素的生化、药理和临床方面，还讨论了它们在某些子宫内膜癌和乳腺癌、子宫内膜异位症的治疗管理以及足月引产中的最终作用。
