Schmiedecke Rudy F, Cassler Nicole M, Fowler Elizabeth M, Sperling Leonard C
Naval Hospital Bremerton, Bremerton, Washington.
Dermatol Online J. 2018 Nov 15;24(11):13030/qt1qv5h1sj.
Acquired progressive kinking of the hair (APK) is a rare disorder that presents at any age and is infrequently presented in the literature. This diagnosis has been used to describe similar hair changes, though there are significant differences in presentation, population, and individual clinical features. Histologic analysis of hair shafts aids in diagnosis owing to commonly reported features such as irregular twisting, bending, and grooving of hair shafts with polygonal shapes on cross-section. We present a case with classic histologic features in an unusual patient to highlight this rare condition. Additional cases and studies are necessary to evaluate etiology, differentiate subsets of APK, and develop both treatment and prevention strategies.
获得性进行性毛发扭结（APK）是一种罕见的疾病，可在任何年龄出现，在文献中很少见。该诊断曾用于描述类似的毛发变化，尽管在表现、人群和个体临床特征方面存在显著差异。由于通常报道的毛干特征，如毛干不规则扭曲、弯曲和有横截面呈多边形的沟纹，毛干的组织学分析有助于诊断。我们报告一例具有典型组织学特征的不寻常患者，以突出这种罕见疾病。需要更多病例和研究来评估病因、区分APK的亚型，并制定治疗和预防策略。
