Nishizawa Yoshitaka, Kanazawa Tetsufumi, Kawabata Yasuo, Matsubara Toshio, Maruyama Soichiro, Kawano Makoto, Kinoshita Shinya, Koh Jun, Matsuo Koji, Yoneda Hiroshi
Department of Neuropsychiatry, Osaka Medical College, Osaka, Japan.
The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.
Psychiatry Investig. 2019 Jan;16(1):80-86. doi: 10.30773/pi.2018.11.12.2. Epub 2019 Jan 25.
Accumulated evidence collected via functional near-infrared spectroscopy (fNIRS) has been reported with regard to mental disorders. A previous finding revealed that emotional words evoke left frontal cortex activity in patients with depression. The primary aim of the current study was to replicate this finding using an independent dataset and evaluate the brain region associated with the severity of depression using an emotional Stroop task.
Oxygenized and deoxygenized hemoglobin recording in the brain by fNIRS on 14 MDD patients and 20 normal controls.
Hyperactivated oxygenized hemoglobin was observed in the left frontal cortex on exposure to unfavorable stimuli, but no significant difference was found among patients with depression compared with healthy controls on exposure to favorable stimuli. This result is consistent with previous findings. Moreover, an evoked wave associated with the left upper frontal cortex on favorable stimuli was inversely correlated with the severity of depression.
Our current work using fNIRS provides a potential clue regarding the location of depression symptom severity in the left upper frontal cortex. Future studies should verify our findings and expand them into a precise etiology of depression.
通过功能近红外光谱技术（fNIRS）收集的关于精神障碍的证据不断积累。先前的一项研究发现，情绪词汇会引发抑郁症患者左额叶皮质的活动。本研究的主要目的是使用独立数据集重复这一发现，并通过情绪Stroop任务评估与抑郁症严重程度相关的脑区。
采用fNIRS对14名重度抑郁症患者和20名正常对照者的大脑进行氧化血红蛋白和脱氧血红蛋白记录。
在暴露于不利刺激时，左额叶皮质观察到氧化血红蛋白过度激活，但在暴露于有利刺激时，抑郁症患者与健康对照者之间未发现显著差异。这一结果与先前的研究结果一致。此外，在有利刺激下与左额上皮质相关的诱发波与抑郁症严重程度呈负相关。
我们目前使用fNIRS的研究为抑郁症症状严重程度在左额上皮质的定位提供了潜在线索。未来的研究应验证我们的发现，并将其扩展为抑郁症的确切病因。
