Department of Medicine, 309953Harbor-UCLA Medical Center, Torrance, CA, USA.
Division of Respiratory and Critical Care Physiology and Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.
J Intensive Care Med. 2020 Dec;35(12):1411-1417. doi: 10.1177/0885066619826044. Epub 2019 Jan 29.
The purpose of this study was to examine how frequently invasive intensive care unit (ICU) treatments are delivered to critically ill patients despite clinicians' impressions that ICU care may be nonbeneficial.
Patients admitted to the medical ICU of an academic public hospital were prospectively categorized according to guidelines from the Society of Critical Care Medicine which classifies patients based on severity of illness and likelihood of recovery (categories 1-4). Clinical data and use of ICU treatments in patients with high (category 1) and low (category 3) likelihoods of benefit were collected by chart review. Multivariable regression analyses examined associations between use of invasive treatments and patient categories, and clinical factors associated with receiving invasive ICU treatments despite low likelihood of benefit.
There were 533 patients (369 in category 1 and 164 in category 3) in the study. A total of 19.8%, 29.9%, and 28.9% of patient-days on mechanical ventilation, vasopressors, and renal replacement therapy, respectively, were delivered to patients who were considered unlikely to benefit from ICU treatments (category 3) and ultimately did not survive hospitalization. These patients also received 35.2% of cardiopulmonary resuscitation attempts and 22.6% of central venous catheter placements. Clinicians' impressions of likelihood of benefit (category 1 vs 3) were not associated with odds of receiving invasive ICU treatments. Clinical characteristics associated with greater odds of receiving potentially nonbeneficial treatments included older age, presence of dementia or malignancy, and higher Acute Physiologic Assessment and Chronic Health Evaluation score.
Invasive ICU treatments are frequently delivered to patients who are not expected to benefit from ICU care and die during hospitalization. These findings highlight the need to improve utilization of ICU services among patients with advanced medical illnesses.
本研究旨在调查尽管临床医生认为 ICU 治疗可能无益,但仍有多少重症患者接受了侵入性的 ICU 治疗。
前瞻性地根据危重病医学会的指南,将入住学术性公立医院 ICU 的患者分类,该指南根据疾病严重程度和恢复可能性对患者进行分类(类别 1-4)。通过病历回顾收集高(类别 1)和低(类别 3)获益可能性患者的临床数据和 ICU 治疗使用情况。多变量回归分析检查了使用侵入性治疗与患者类别之间的关联,以及与尽管获益可能性低但仍接受侵入性 ICU 治疗相关的临床因素。
本研究共纳入 533 例患者(类别 1 患者 369 例,类别 3 患者 164 例)。在考虑不太可能从 ICU 治疗中获益(类别 3)且最终住院期间未存活的患者中,机械通气、血管加压素和肾脏替代治疗的患者天数分别为 19.8%、29.9%和 28.9%。这些患者还接受了 35.2%的心肺复苏尝试和 22.6%的中心静脉置管。临床医生对获益可能性的印象(类别 1 与 3)与接受侵入性 ICU 治疗的几率无关。与接受潜在无益治疗的几率较高相关的临床特征包括年龄较大、痴呆或恶性肿瘤的存在,以及较高的急性生理学和慢性健康评估评分。
频繁对预计无法从 ICU 护理中获益且在住院期间死亡的患者提供侵入性 ICU 治疗。这些发现强调了需要改进患有晚期内科疾病患者的 ICU 服务利用。