Instituto Universitario del Gran Rosario (IUGR), Centro Universitario de Asistencia, Docencia e Investigación (CUADI), Unidad de Investigación Musculoesquelética (UIM), Argentina.
Med Hypotheses. 2019 Feb;123:101-109. doi: 10.1016/j.mehy.2019.01.009. Epub 2019 Jan 11.
Lateral epicondylalgia (LE) is the most common chronic painful condition affecting the elbow in the general population. Although major advances have been accomplished in recent years in the understanding of LE, the underlying physiopathology is still a reason for debate. Differences in clinical presentation and evolution of the symptoms among patients, suggest the need for revisiting the current knowledge about subjacent mechanisms that attempt to explain pain and functional loss. Previous models have suggested that the condition is mainly a degenerative tendinopathy, associated with changes in pain pathways and the motor system. The hypothesis of this work is that LE is the clinical manifestation of a primary nervous system disorder, characterized by an abnormal increase in neuronal activity and a subsequent loss of homeostasis, which secondarily affects the musculoskeletal tissues of the elbow-forearm-hand complex. A new model for LE is presented, supported by an in-deep analysis of basic sciences, epidemiological and clinical studies.
外侧肱骨上髁炎（LE）是最常见的影响一般人群肘部的慢性疼痛疾病。尽管近年来在 LE 的理解方面取得了重大进展，但潜在的病理生理学仍然存在争议。患者的临床表现和症状演变存在差异，这表明需要重新审视当前关于试图解释疼痛和功能丧失的潜在机制的知识。先前的模型表明，这种情况主要是一种退行性肌腱病，与疼痛途径和运动系统的变化有关。这项工作的假设是，LE 是一种主要的神经系统疾病的临床表现，其特征是神经元活动异常增加和随后的平衡失调，这会继发影响肘-前臂-手复合体的肌肉骨骼组织。提出了一种新的 LE 模型，该模型得到了基础科学、流行病学和临床研究的深入分析的支持。
