Department of Otorhinolaryngology-Head and Neck Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea.
Department of Otorhinolaryngology-Head and Neck Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea.
Med Hypotheses. 2019 Feb;123:55-59. doi: 10.1016/j.mehy.2018.12.017. Epub 2018 Dec 24.
Light cupula is an emerging concept accounting for positional nystagmus. It can be diagnosed when persistent geotropic direction-changing positional nystagmus (PG DCPN) is observed in a head-roll test. Although hypotheses explaining light cupula phenomenon such as "light debris", "lighter cupula", and "heavier endolymph" have been proposed, the mechanism underlying light cupula has not been clearly elucidated yet. In the present study, we proposed a new hypothesis accounting for light cupula, i.e., density difference between perilymph and endolymph could elicit characteristic PG DCPN in a head-roll test. We also discussed the mechanism how membranous canal containing endolymph became buoyant within the perilymphatic space under constant influence of gravity when the density of perilymph was higher than that of endolymph.
轻嵴帽是一种新兴的概念，用于解释位置性眼球震颤。当头倾斜试验中观察到向地性位置性眼球震颤（PG DCPN）持续存在时，可以诊断为轻嵴帽。尽管已经提出了解释轻嵴帽现象的假说，如“轻碎片”、“更轻的嵴帽”和“更重的内淋巴液”，但轻嵴帽的机制尚未得到明确阐明。在本研究中，我们提出了一个新的假说，即外淋巴液和内淋巴液之间的密度差异可以在头倾斜试验中引起特征性的 PG DCPN。我们还讨论了当外淋巴液的密度高于内淋巴液时，膜性管腔内充满内淋巴液如何在重力的持续作用下在鞘内空间内漂浮的机制。
