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发展中国家肌肉骨骼肿瘤切除术后的低成本重建方案。经济实惠、有效且持久的替代方案。

Low cost reconstructive options after musculoskeletal tumour resection in developing countries. Affordable, effective and durable alternatives.

作者信息

Ali Arif, Hasan Obada, Habib Ahmed, Umer Masood

机构信息

Department of Surgery, Aga Khan University, Karachi, Pakistan.

出版信息

J Pak Med Assoc. 2019 Feb;69(Suppl 1)(1):S72-S76.

Abstract

Over the last two, three decades, the overall survival rates for non-metastatic malignant tumours of the bone have dramatically improved. This has become possible due to the recent advances and multidisciplinary approach towards these diseases, specifically the advent of multi-agent chemotherapy and radiotherapy. Limb salvage has now become the norm in the treatment of musculoskeletal tumours without compromising on the overall survival and recurrence of the disease. In the era of metal, prosthetic reconstruction has become the standard procedure specifically in the large tumours which involve the joints as this method of reconstruction helps in joint mobility and early weight-bearing. Considering the costs and resource constraints, multiple cost-effective, stable, durable reconstruction options have evolved over the last decade and these have also shown favourable func tional outcomes without compromising on the amount of resection and risk of local recurrence. The current literature review was planned to discuss various cost-effective, durable reconstructive options and their advantages and disadvantages. These include Van ness rotationplasty, allograft, autograft, devitalised tumour bone and Masqueletor induced membrane technique . .

摘要

在过去的二三十年里,非转移性骨恶性肿瘤的总体生存率有了显著提高。这得益于近年来针对这些疾病的进展和多学科方法,特别是多药化疗和放疗的出现。保肢现已成为治疗肌肉骨骼肿瘤的常规方法,且不影响疾病的总体生存率和复发率。在金属时代,假体重建已成为涉及关节的大型肿瘤的标准手术,因为这种重建方法有助于关节活动和早期负重。考虑到成本和资源限制,在过去十年中出现了多种具有成本效益、稳定、持久的重建选择,这些选择在不影响切除范围和局部复发风险的情况下也显示出良好的功能结果。本次文献综述旨在讨论各种具有成本效益、持久的重建选择及其优缺点。这些包括范内斯旋转成形术、同种异体移植、自体移植、失活肿瘤骨和马斯克莱托诱导膜技术。

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