Zekry Karem M, Yamamoto Norio, Hayashi Katsuhiro, Takeuchi Akihiko, Higuchi Takashi, Abe Kensaku, Taniguchi Yuta, Alkhooly Ali Zein A A, Abd-Elfattah Ahmed Saleh, Fouly Ezzat H, Ahmed Adel Refaat, Tsuchiya Hiroyuki
Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Department of Orthopaedic Surgery, Faculty of Medicine, Minia University, Minya, Egypt.
Int Orthop. 2017 Jul;41(7):1481-1487. doi: 10.1007/s00264-017-3446-x. Epub 2017 Mar 25.
In 1999, we developed a technique using frozen autografts-tumour-containing bone treated with liquid nitrogen-for the reconstruction of malignant bone tumours. The purpose of this study was to evaluate the functional and oncological outcomes of frozen autografts for intercalary reconstruction of malignant bones and soft tissue tumours.
This retrospective study was designed to assess 34 patients of mean age 35 (range, 6-79) years. The mean follow-up period was 62 (24-214) months. The median length of the frozen autografts was 138.4 ± 60.39 (50-290) mm.
Postsurgically, 20 patients remained disease-free, seven patients survived with no evidence of disease, five patients were alive with disease, and two patients died of disease. The five- and ten-year survival rates of the frozen autografts were 91.2% and the mean International Society of Limb Salvage score was 90%. Complete bony union was achieved in 97% of the patients. There were five cases of nonunion, six cases of fracture, two cases of deep infection and four cases of local recurrence.
Utilizing intercalary frozen autografts for patients with a nonosteolytic primary or secondary bone tumour without involvement of the subchondral bone is a good alternative treatment, because it is a straightforward biological technique and can provide excellent limb function.
1999年，我们研发了一种使用经液氮处理的含肿瘤自体骨冷冻移植技术来重建恶性骨肿瘤。本研究的目的是评估冷冻自体骨用于恶性骨与软组织肿瘤节段性重建的功能及肿瘤学结果。
本回顾性研究旨在评估34例平均年龄35岁（范围6 - 79岁）的患者。平均随访期为62个月（24 - 214个月）。冷冻自体骨的中位长度为138.4 ± 60.39毫米（50 - 290毫米）。
术后，20例患者无疾病复发，7例患者存活且无疾病证据，5例患者带瘤存活，2例患者死于疾病。冷冻自体骨的5年和10年生存率为91.2%，平均国际保肢协会评分为90%。97%的患者实现了完全骨愈合。有5例骨不连、6例骨折、2例深部感染和4例局部复发。
对于无软骨下骨受累的非溶骨性原发性或继发性骨肿瘤患者，采用节段性冷冻自体骨移植是一种良好的替代治疗方法，因为它是一种直接简便的生物学技术，且能提供出色的肢体功能。
