Alipour Ramin, Smith Steven, Gupta Sandeep K
Department of Nuclear Medicine and PET, John Hunter and Calvary Mater Hospitals Newcastle NSW, Australia.
University of Newcastle NSW, Australia.
Am J Nucl Med Mol Imaging. 2018 Dec 20;8(6):415-420. eCollection 2018.
Differentiation of benign and malignant parotid uptake on Fluorine 18 Fluro-Deoxy-Glucose Positron Emission Tomography-Computed Tomography (F FDG PET-CT) is of paramount importance due to the poor prognosis of the later but usual quantitative measures such as standardized uptake value (SUV) are not reliable for this purpose. Metabolic heterogeneity, being a characteristic of malignant tumors, would potentially be able to make this distinction. In this study, seventy-one FDG-avid parotid lesions were retrospectively separated histologically into benign and malignant groups. The heterogeneity factor (HF) of all the lesions was then calculated and compared between the two groups. There was significant difference in HF between malignant (median -0.17) and benign group (median -0.03); =0.0006. On receiver operating characteristic (ROC) analysis, a cut-off value of ≤ -0.06 for HF was associated with the highest sensitivity and specificity (sensitivity and specificity of 94.6% and 60.0%, respectively-AUC=0.789; =0.0001). Hence, it was concluded that HF is a reliable value in distinguishing benign from malignant parotid uptake on F FDG PET-CT.
在氟代脱氧葡萄糖正电子发射断层扫描-计算机断层扫描（F-FDG PET-CT）上区分腮腺摄取的良性和恶性至关重要，因为后者预后较差，但诸如标准化摄取值（SUV）等常用定量指标在此用途上并不可靠。代谢异质性作为恶性肿瘤的一个特征，可能有能力做出这种区分。在本研究中，71个FDG摄取阳性的腮腺病变经组织学回顾性分为良性和恶性组。然后计算所有病变的异质性因子（HF）并在两组之间进行比较。恶性组（中位数为-0.17）和良性组（中位数为-0.03）的HF存在显著差异；P=0.0006。在受试者工作特征（ROC）分析中，HF≤-0.06的临界值具有最高的敏感性和特异性（敏感性和特异性分别为94.6%和60.0%-AUC=0.789；P=0.0001）。因此，得出结论：在F-FDG PET-CT上，HF是区分腮腺摄取良性和恶性的可靠指标。
