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生长分化因子-15 与心血管疾病和全因死亡率的风险:前瞻性研究的荟萃分析。

Growth differentiation factor-15 and the risk of cardiovascular diseases and all-cause mortality: A meta-analysis of prospective studies.

机构信息

Department of Clinical Laboratory, Shengjing Hospital of China Medical University, Shenyang, China.

出版信息

Clin Cardiol. 2019 May;42(5):513-523. doi: 10.1002/clc.23159. Epub 2019 Mar 26.

Abstract

BACKGROUND AND AIM

Previous studies have documented that the association between growth differentiation factor-15 (GDF-15) the risk of patients with cardiovascular diseases (CVDs). In this meta-analysis, our main objective is to explore the associations between GDF-15 and the risk of CVD or all-cause mortality.

METHODS

PubMed and ISI Web of Science (up to January 2018) electronic databases were browsed for eligible studies. The studies provided relevant data depicted as hazard ratio (HR) with 95% confidence interval (CI), with regard to the association between GDF-15 levels and subsequent risk of CVDs or all-cause mortality. A random-effect model was applied to pool the HR and 95% CI.

RESULTS

Thirty-one prospective studies met the eligibility criteria involving 53 706 subjects with 7020 adverse outcome events. It was concluded that GDF-15 levels were associated with an incremental risk of CVDs or all-cause mortality. Highest GDF-15 category was associated with greater risk of cardiovascular mortality (HR, 2.66; 95% CI, 1.69-3.63), all-cause mortality (HR, 2.52; 95% CI, 2.06-2.97), and complex adverse outcome (HR, 1.81; 95% CI, 1.42-2.21). As each log-unit increment in GDF-15 concentration, the corresponding risk of adverse events also escalated, cardiovascular mortality (HR, 2.11; 95% CI, 1.57-2.66), all-cause mortality (HR, 2.70; 95% CI, 2.29-3.12), and complex adverse outcome (HR, 1.96; 95% CI, 1.64-2.29).

CONCLUSIONS

Judging from the results of the data analysis, GDF-15 levels may increase the risk of CVDs or all-cause mortality.

摘要

背景与目的

先前的研究已经证明,生长分化因子 15(GDF-15)与心血管疾病(CVDs)患者的风险之间存在关联。在本荟萃分析中,我们的主要目的是探讨 GDF-15 与 CVD 或全因死亡率风险之间的关联。

方法

检索 PubMed 和 ISI Web of Science(截至 2018 年 1 月)电子数据库,以获取符合条件的研究。这些研究提供了与 GDF-15 水平与随后 CVDs 或全因死亡率风险之间的相关性相关的风险比(HR)和 95%置信区间(CI)。应用随机效应模型来合并 HR 和 95%CI。

结果

31 项符合条件的前瞻性研究共纳入 53706 名受试者,其中 7020 名发生不良结局事件。结果表明,GDF-15 水平与 CVDs 或全因死亡率的风险增加相关。最高 GDF-15 类别与心血管死亡率(HR,2.66;95%CI,1.69-3.63)、全因死亡率(HR,2.52;95%CI,2.06-2.97)和复杂不良结局(HR,1.81;95%CI,1.42-2.21)的风险增加相关。随着 GDF-15 浓度每增加一个对数单位,不良事件的相应风险也会上升,包括心血管死亡率(HR,2.11;95%CI,1.57-2.66)、全因死亡率(HR,2.70;95%CI,2.29-3.12)和复杂不良结局(HR,1.96;95%CI,1.64-2.29)。

结论

从数据分析的结果来看,GDF-15 水平可能会增加 CVDs 或全因死亡率的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93e9/6523003/9e5ec9627297/CLC-42-513-g001.jpg

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