1 School of Psychology, University of New South Wales, Sydney, NSW, Australia.
2 College of Health and Medicine, University of Tasmania, Hobart, TAS, Australia.
J Psychopharmacol. 2019 Mar;33(3):364-371. doi: 10.1177/0269881118822074. Epub 2019 Jan 30.
Administration of smoking cessation medications in anticipation of a nominated quit date can promote abstinence. How this occurs is not widely understood, but may be due to the disruption of contingencies between smoking behaviour and acute drug effects.
The aim of this study was to explore this relationship, we examined the effect of pre-quit nicotine replacement therapy on susceptibility to relapse in an animal model of nicotine dependence.
Rats were trained to intravenously self-administer nicotine across 20 days. Continuous low-dose nicotine was administered via a mini-osmotic pump either across the last 7 days of self-administration and across 6 days of extinction, or across extinction only. Cue- and drug-induced reinstatements of responding were then measured with mini-pumps retained, the day after mini-pump removal or one week later.
Pre-quit nicotine administration markedly reduced self-administration across the last days of training as the response, and its associated cues, no longer reliably predicted an acute drug effect. Pre-quit, but not post-quit, nicotine administration significantly attenuated cue-induced reinstatement once mini-pumps were removed, indicating that the contingency disruption across training reduced the conditioned reinforcing properties of the cue at test. Both pre-quit and post-quit nicotine attenuated nicotine-primed reinstatement.
Together these results suggest that administration of a nicotine replacement prior to a nominated quit date may enhance resistance to relapse via disruption of the contingency between a response, its associated cues, and a rewarding nicotine effect.
在指定的戒烟日期前使用戒烟药物可以促进戒烟。但是，这种方法的具体机制还不是很清楚，可能是因为打破了吸烟行为和急性药物作用之间的联系。
本研究旨在探讨这种联系，我们在尼古丁依赖动物模型中检查了戒烟前尼古丁替代疗法对复发易感性的影响。
训练大鼠通过静脉内自我注射尼古丁 20 天。通过微型渗透泵在最后 7 天的自我给药期间和 6 天的消退期间连续给予低剂量尼古丁，或者仅在消退期间给予。然后在保留微型泵的情况下，在微型泵取出后的第二天或一周后测量线索和药物引起的反应恢复。
戒烟前的尼古丁给药显著减少了训练最后几天的自我给药，因为反应及其相关线索不再可靠地预测急性药物作用。戒烟前但不是戒烟后的尼古丁给药显著减轻了线索引起的反应恢复，这表明在训练期间破坏了联系，降低了测试中线索的条件强化特性。戒烟前和戒烟后的尼古丁都减弱了尼古丁引发的反应恢复。
这些结果表明，在指定的戒烟日期前使用尼古丁替代物可能会通过破坏反应、相关线索和奖励性尼古丁作用之间的联系来增强对复发的抵抗力。
