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踝关节骨软骨异体移植失败后挽救性关节融合和关节置换的结果。

Outcomes of Salvage Arthrodesis and Arthroplasty for Failed Osteochondral Allograft Transplantation of the Ankle.

机构信息

1 Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA, USA.

2 Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.

出版信息

Foot Ankle Int. 2019 May;40(5):537-544. doi: 10.1177/1071100718824082. Epub 2019 Jan 30.

Abstract

BACKGROUND

Osteochondral allograft (OCA) transplantation is a useful treatment for posttraumatic ankle arthritis in young patients, but failure rates are high and reoperations are not uncommon. The aim of this study was to evaluate the outcomes of failed ankle OCA transplantation converted to ankle arthrodesis (AA) or total ankle arthroplasty (TAA).

METHODS

We evaluated 24 patients who underwent salvage procedures (13 AA and 11 TAA) after primary failed ankle OCA transplantation. Reoperations were assessed. Failure of the salvage procedure was defined as an additional surgery that required a revision AA/TAA or amputation. Evaluation among nonfailing ankles included the American Academy of Orthopaedic Surgeons Foot and Ankle Module (AAOS-FAM), pain, and satisfaction.

RESULTS

In the salvage AA cohort, 3 patients were classified as failures (2 revision AA and 1 amputation). The 10 nonfailing patients had a mean follow-up of 7.4 years. Eighty-eight percent were satisfied with the procedure, but 63% reported continued problems with their ankle (eg, pain, swelling, stiffness). Mean pain level was 1.9 and AAOS-FAM core score was 83±13. In the salvage TAA cohort, 2 patients were classified as failures (both revision TAA). The 9 nonfailing patients had a mean follow-up of 3.8 years. Fifty percent were satisfied with the procedure, but 40% reported continued problems with their ankle. The mean pain level was 1.3, and the median AAOS-FAM core score was 82±26.

CONCLUSION

Revision and reoperation rates for salvage procedures following failed OCA transplantation of the ankle are higher compared to published data for primary AA and TAA procedures. However, we believe OCA transplantation can serve as an interim procedure for younger patients with advanced ankle joint disease who may not be ideal candidates for primary AA or TAA at the time of initial presentation.

LEVEL OF EVIDENCE

Level IV, case series.

摘要

背景

同种异体骨软骨移植(OCA)是治疗年轻患者创伤后踝关节关节炎的有效方法,但失败率较高,且翻修手术并不少见。本研究旨在评估初次 OCA 移植失败后改行踝关节融合术(AA)或全踝关节置换术(TAA)的疗效。

方法

我们评估了 24 例初次 OCA 移植失败后行挽救性手术(13 例 AA 和 11 例 TAA)的患者。评估了再手术的结果。挽救性手术失败定义为需要再次行 AA/TAA 翻修或截肢的手术。非失败踝关节的评估包括美国矫形外科医师学会足踝模块(AAOS-FAM)评分、疼痛和满意度。

结果

在挽救性 AA 组中,3 例患者(2 例再次行 AA,1 例截肢)被归类为失败。10 例非失败患者的平均随访时间为 7.4 年。88%的患者对手术满意,但 63%的患者仍存在踝关节问题(如疼痛、肿胀、僵硬)。平均疼痛评分为 1.9,AAOS-FAM 核心评分 83±13。在挽救性 TAA 组中,2 例患者(均再次行 TAA)被归类为失败。9 例非失败患者的平均随访时间为 3.8 年。50%的患者对手术满意,但 40%的患者仍存在踝关节问题。平均疼痛评分为 1.3,AAOS-FAM 核心评分中位数为 82±26。

结论

与初次 AA 和 TAA 手术相比,初次 OCA 移植失败后行挽救性手术的翻修和再手术率更高。然而,我们认为 OCA 移植可作为年轻患者踝关节疾病进展的一种过渡性手术,这些患者初次就诊时可能不适合行初次 AA 或 TAA。

证据等级

IV 级,病例系列研究。

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