[睡眠-觉醒周期与Panx1突变的实验模型]
[Sleep-wake cycle and experimental models of Panx1 mutations].
作者信息
Kovalzon V M, Latyshkova A A, Komarova A D, Panchin Yu V
机构信息
Severtsov Institute of Ecology and Evolution of the Russian Academy of Sciences, Moscow, Russia; Kharkhevich Institute of Information Transmission of the Russian Academy of Sciences, Moscow, Russia.
Kharkhevich Institute of Information Transmission of the Russian Academy of Sciences, Moscow, Russia; Lomonosov Moscow State University, Moscow, Russia.
出版信息
Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(12):61-64. doi: 10.17116/jnevro201811812161.
AIM
To test the hypothesis of a possible role of the Panx1 (pannexin-1) mutation in changing the sleep - wake cycle.
MATERIAL AND METHODS
Continuous 24 h recording of the EEG and movement activity in Panx1 knockout and wild type mice was performed.
RESULTS AND CONCLUSION
A significant increase in wake percentage at the expense of a decrease in slow-wave sleep was found in knockout mice as compared to the control ones. The difference was especially pronounced during the 12-h dark period in the chamber. Also, an increase in the movement activity was clearly seen in knockout mice. The results are compared to a recent case-report of a Panx1 female patient with homozygote's mutation in this gene. The role of Panx1 protein in normal as well as pathological physiology is discussed.
目的
验证Panx1（泛连接蛋白-1）突变在改变睡眠-觉醒周期中可能发挥作用的假说。
材料与方法
对Panx1基因敲除小鼠和野生型小鼠进行连续24小时的脑电图和运动活动记录。
结果与结论
与对照小鼠相比，基因敲除小鼠的觉醒百分比显著增加，慢波睡眠减少。这种差异在实验箱内12小时的黑暗期尤为明显。此外，基因敲除小鼠的运动活动也明显增加。将这些结果与最近一篇关于一名该基因纯合突变的Panx1女性患者的病例报告进行了比较。讨论了Panx1蛋白在正常及病理生理学中的作用。
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