Department of Neurosurgery, University of Erlangen-Nuremberg, Erlangen, Germany,
Department of Neurosurgery, University of Erlangen-Nuremberg, Erlangen, Germany.
Neuroendocrinology. 2019;109(1):77-81. doi: 10.1159/000497331. Epub 2019 Jan 30.
While in the past surgery for prolactinomas was a competitive option to medical treatment with dopamine agonists, to date the indications for operations are restricted to only a few specific situations. However, if a patient is intolerant to medical treatment or if the drugs are not sufficiently effective in terms of lowering prolactin levels or tumor shrinkage, surgery should always be considered. In microprolactinomas, operations can achieve excellent prolactin normalization rates. In tumors difficult to treat, the combination of surgical tumor resection and long-term medical treatment supports better control of the disease. The individual indications, results, techniques, and complications of operations for prolactinomas are briefly reviewed in this paper.
虽然过去对于泌乳素瘤的治疗，手术曾是多巴胺激动剂药物治疗的一种竞争选择，但目前手术的适应证仅限于少数特定情况。然而，如果患者不能耐受药物治疗，或者药物在降低泌乳素水平或肿瘤缩小方面效果不够理想，那么手术就应始终被考虑。在微腺瘤中，手术可以实现非常好的泌乳素正常化率。对于难以治疗的肿瘤，手术切除肿瘤联合长期药物治疗可以更好地控制疾病。本文简要回顾了泌乳素瘤手术的适应证、结果、技术和并发症。
