EENT Hospital, Fudan University, Shanghai, China.
Hainan (Boao) International Eye Hospital, Hainan, China.
Ophthalmologica. 2019;242(2):59-68. doi: 10.1159/000495423. Epub 2019 Jan 30.
This study evaluates the efficacy and patient satisfaction of intravitreal conbercept (IVC) as adjunctive treatment before panretinal photocoagulation (PRP) for Chinese proliferative diabetic retinopathy (PDR) with or without clinically significant macular edema.
We enrolled 94 patients and categorized them into 2 groups: eyes that received PRP with single-dose IVC (0.5 mg/0.05 mL) 1 week before PRP (Plus group) or PRP only (PRP group). We measured the central macular thickness (CMT) by optical coherence tomography and best-corrected visual acuity. Satisfaction of PRP after 3 months was evaluated by a satisfaction questionnaire.
Single-dose IVC 1 week before PRP significantly increased the PRP completion rate and satisfaction of treatment after 3 months in PDR patients. The average CMT significantly decreased in the Plus group but increased in the PRP group. No average visual changes were detected in the Plus group, but significant average visual loss was detected in the PPR group. The most important factors that determined satisfaction were the PRP completion rate in the short term and better vision gain after PRP.
IVC is a promising adjunctive treatment to PRP in the treatment of PDR. Single-dose IVC 1 week before PRP was suggested to improve PRP completion rate and patient satisfaction in the short term.
本研究评估了玻璃体腔内康柏西普（IVC）作为辅助治疗在全视网膜光凝（PRP）前对中国增生型糖尿病视网膜病变（PDR）伴或不伴临床显著黄斑水肿的疗效和患者满意度。
我们纳入了 94 名患者，并将他们分为两组：一组在 PRP 前 1 周接受单次剂量 IVC（0.5mg/0.05ml）的 PRP（加药组），另一组仅接受 PRP（PRP 组）。我们通过光学相干断层扫描和最佳矫正视力测量中央黄斑厚度（CMT）。通过满意度问卷评估 3 个月后 PRP 的满意度。
PRP 前 1 周单次剂量 IVC显著提高了 PDR 患者 PRP 的完成率和 3 个月后的治疗满意度。加药组的平均 CMT 显著降低，而 PRP 组则增加。加药组平均视力无明显变化，但 PRP 组平均视力明显下降。决定满意度的最重要因素是短期 PRP 完成率和 PRP 后视力提高。
IVC 是 PRP 治疗 PDR 的一种有前途的辅助治疗方法。PRP 前 1 周单次剂量 IVC 可提高 PRP 的完成率和短期患者满意度。
