Hamaguchi K, Miyahara K, Nishimura H, Tashiro M, Kishi N, Matsumura T, Yakushiji M, Kato T
Department of Obstetrics and Gynecology, Kurume University School of Medicine.
Nihon Sanka Fujinka Gakkai Zasshi. 1988 Nov;40(11):1755-9.
The antitumor activity of new platinum analogs was studied at equitoxic doses to that of cisplatin (CDDP) in BALB/C nu-nu nude mice bearing xenografts of human ovarian malignant tumors. The following two tumor lines were used: OH-1 (serous cystadenocarcinoma) and MP-1 (mucinous cystadenoma, LPM). 1) Antitumor activity was determined for all agents from the T/C ratio for OH-1. In particular, 254-S and JM-8 were found to be much more active than the other agents. 2) Antitumor activity was determined with JM-8 from the abdominal diameter ratio for MP-1. Both JM-8 and CDDP yielded active responses which were evaluated by the CEA value. Therefore, JM-8 and CDDP were considered to be the most active agents for MP-1. 3) We evaluated the mean body weight loss of tumor bearing mice in order to study the side effects, and a great weight loss was observed with 254-S. 4) A large variety of effects were observed in the histological evaluation for the two tumor lines, and were thus difficult to discuss. Our findings suggest the necessity of individual chemotherapy for each histological type of ovarian malignant tumor.
在携带人卵巢恶性肿瘤异种移植瘤的BALB/C裸鼠中，以与顺铂（CDDP）等效毒性剂量研究了新型铂类类似物的抗肿瘤活性。使用了以下两种肿瘤细胞系：OH-1（浆液性囊腺癌）和MP-1（黏液性囊腺瘤，低级别浆液性癌）。1）根据OH-1的T/C比值测定所有药物的抗肿瘤活性。特别地，发现254-S和JM-8比其他药物活性更强。2）根据MP-1的腹径比值用JM-8测定抗肿瘤活性。JM-8和CDDP均产生了活性反应，通过癌胚抗原（CEA）值进行评估。因此，JM-8和CDDP被认为是对MP-1最具活性的药物。3）为了研究副作用，我们评估了荷瘤小鼠的平均体重减轻情况，观察到254-S导致了大量体重减轻。4）在对两种肿瘤细胞系的组织学评估中观察到了各种各样的效应，因此难以进行讨论。我们的研究结果表明，对于每种组织学类型的卵巢恶性肿瘤，有必要进行个体化化疗。
