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腰椎脊柱手术后的再次手术:使用临床实践研究数据链接(CPRD)和医院入院统计(HES)的英国人群队列研究中的成本和结果。

Reoperation following lumbar spinal surgery: costs and outcomes in a UK population cohort study using the Clinical Practice Research Datalink (CPRD) and Hospital Episode Statistics (HES).

机构信息

PHMR, Ltd., Bldg D, Berkeley Works, Berkley Grove, London, NW1 8XY, UK.

Harvard Medical School, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.

出版信息

Eur Spine J. 2019 Apr;28(4):863-871. doi: 10.1007/s00586-018-05871-5. Epub 2019 Jan 30.

Abstract

PURPOSE

To assess the likelihood of persistent postoperative pain (PPP) following reoperation after lumbar surgery and to estimate associated healthcare costs.

METHODS

This is a retrospective cohort study using two linked UK databases: Hospital Episode Statistics and UK Clinical Practice Research Datalink. Costs and outcomes associated with reoperation were evaluated over a 2-year postoperative period using multivariate logistic regression for cases who underwent reoperation and controls who did not, based on demographics, index surgery type, smoking status, and pre-index comorbidities using propensity score matching.

RESULTS

Risk factors associated with reoperation included younger age and the presence of diabetes with complications or rheumatic disease. The rate of PPP after reoperation was much higher than after index surgery, with 79 of 200 (39.5%; 95% CI 32.5%, 46.5%) participants experiencing ongoing pain compared with 983 of 5022 (19.5%; 95% CI 18.5%, 20.7%) after index surgery. Mean costs in the 2 years following reoperation were £1889 higher (95% CI £2, £3809) than for patients with PPP who did not undergo repeat surgery over an equivalent follow-up period. With the cost of reoperation itself included, the mean cost difference for patients who underwent reoperation compared with matched controls rose to £7221 (95% CI £5273, £9206).

CONCLUSIONS

High rates of PPP and associated healthcare costs suggest that returning to the operating room is a complex and challenging decision. Spinal surgeons should review whether the potential benefits of additional surgery are justified when other approaches to managing and relieving chronic pain have demonstrated superior outcomes. These slides can be retrieved under Electronic Supplementary Material.

摘要

目的

评估腰椎手术后再次手术患者持续术后疼痛(PPP)的可能性,并估算相关医疗保健成本。

方法

这是一项使用英国两个相关数据库(医院病例统计数据库和英国临床实践研究数据链)的回顾性队列研究。通过多变量逻辑回归,对接受再次手术的病例和未接受再次手术的对照患者(基于人口统计学、索引手术类型、吸烟状况和术前合并症,采用倾向评分匹配)在术后 2 年内与再次手术相关的成本和结果进行评估。

结果

与再次手术相关的风险因素包括年龄较小以及患有糖尿病伴并发症或风湿性疾病。与索引手术相比,再次手术后 PPP 的发生率要高得多,200 名接受再次手术的患者中有 79 名(39.5%;95%CI 32.5%,46.5%)持续存在疼痛,而 5022 名接受索引手术的患者中有 983 名(19.5%;95%CI 18.5%,20.7%)。与在同等随访期间未接受重复手术的 PPP 患者相比,再次手术后 2 年内的平均费用高出 1889 英镑(95%CI 2,3809 英镑)。如果将再次手术的费用包括在内,与匹配对照组相比,接受再次手术的患者的平均费用差异上升至 7221 英镑(95%CI 5273,9206 英镑)。

结论

PPP 发生率高且相关医疗保健成本高表明,重返手术室是一个复杂且具有挑战性的决策。脊柱外科医生应评估在其他治疗和缓解慢性疼痛的方法已显示出更优结果的情况下,额外手术的潜在益处是否合理。这些幻灯片可在电子补充材料中检索。

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